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  1. No Access

    Article

    Intrinsic targeting of host RNA by Cas13 constrains its utility

    Cas13 can be used for the knockdown, editing, imaging or detection of RNA and for RNA-based gene therapy. Here by using RNA immunoprecipitation sequencing, transcriptome profiling, biochemical analysis, high-t...

    Zexu Li, Zihan Li, **aolong Cheng, Shengnan Wang… in Nature Biomedical Engineering (2024)

  2. No Access

    Article

    Quantitative assessment of fire occurrence Dead Fuel Index threshold and spatio-temporal variation in different grassland types of China-Mongolia border area

    Climate change is manifesting rapidly in the form of fires, droughts, floods, resource scarcity, and species loss, and remains a global risk. Owing to the disaster risk management, there is a need to determine...

    Lumen Chao, Yulong Bao, Jiquan Zhang, Yuhai Bao, Li Mei… in Journal of Geographical Sciences (2023)

  3. Article

    Open Access

    Modeling CRISPR-Cas13d on-target and off-target effects using machine learning approaches

    A major challenge in the application of the CRISPR-Cas13d system is to accurately predict its guide-dependent on-target and off-target effect. Here, we perform CRISPR-Cas13d proliferation screens and design a ...

    **aolong Cheng, Zexu Li, Ruocheng Shan, Zihan Li, Shengnan Wang… in Nature Communications (2023)

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  4. No Access

    Article

    Piezoelectric KNN ceramic for energy harvesting from mechanochemically activated precursors

    In this study, a high quality Na0.52K0.435Li0.045Nb0.905Ta0.05Sb0.045O3 (LS45-H) ceramic has been prepared from mechanochemically activated LS45 powder and normal sintering in air, which is promising for use in l...

    Mupeng Zheng, Yudong Hou, Lumen Chao… in Journal of Materials Science: Materials in… (2018)