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  1. Article

    Open Access

    The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice

    Investigating neurovascular coupling in awake rodents is becoming ever more popular due, in part, to our increasing knowledge of the profound impacts that anaesthesia can have upon brain physiology. Although a...

    Beth Eyre, Kira Shaw, Paul Sharp, Luke Boorman, Llywelyn Lee in Scientific Reports (2022)

  2. Article

    Open Access

    Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease

    Early impairments to neurovascular coupling have been proposed to be a key pathogenic factor in the onset and progression of Alzheimer’s disease (AD). Studies have shown impaired neurovascular function in seve...

    Osman Shabir, Paul Sharp, Monica A. Rebollar, Luke Boorman in Scientific Reports (2020)

  3. No Access

    Chapter and Conference Paper

    A Bioinspired Approach to Vision

    This paper describes the design of a computational vision framework inspired by the cortices of the brain. The proposed framework carries out visual saliency and provides pathways through which object segmenta...

    Daniel Camilleri, Luke Boorman, Uriel Martinez in Towards Autonomous Robotic Systems (2016)

  4. Article

    Open Access

    Correction: Corrigendum: Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime

    Neural activity is closely followed by a localised change in cerebral blood flow, a process termed neurovascular coupling. These hemodynamic changes form the basis of contrast in functional magnetic resonance ...

    Paul S. Sharp, Kira Shaw, Luke Boorman, Samuel Harris in Scientific Reports (2015)

  5. Article

    Open Access

    Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime

    Neural activity is closely followed by a localised change in cerebral blood flow, a process termed neurovascular coupling. These hemodynamic changes form the basis of contrast in functional magnetic resonance ...

    Paul S. Sharp, Kira Shaw, Luke Boorman, Samuel Harris in Scientific Reports (2015)

  6. No Access

    Chapter and Conference Paper

    A Top-Down Approach for a Synthetic Autobiographical Memory System

    Autobiographical memory (AM) refers to the organisation of one’s experience into a coherent narrative. The exact neural mechanisms responsible for the manifestation of AM in humans are unknown. On the other ha...

    Andreas Damianou, Carl Henrik Ek, Luke Boorman in Biomimetic and Biohybrid Systems (2015)

  7. No Access

    Chapter and Conference Paper

    ROBO-GUIDE: Towards Safe, Reliable, Trustworthy, and Natural Behaviours in Robotic Assistants

    In this paper we describe a novel scenario, whereby an assistive robot is required to use a lift, and results from a preliminary investigation into floor determination using readily-available information. The ...

    James Law, Jonathan M. Aitken, Luke Boorman in Towards Autonomous Robotic Systems (2015)

  8. No Access

    Chapter and Conference Paper

    Help! I Can’t Reach the Buttons: Facilitating Hel** Behaviors Towards Robots

    Human-Robot-Interaction (HRI) research is often built around the premise that the robot is serving to assist a human in achieving a human-led goal or shared task. However, there are many circumstances during H...

    David Cameron, Emily C. Collins, Adriel Chua in Biomimetic and Biohybrid Systems (2015)

  9. No Access

    Protocol

    Simultaneous Functional Magnetic Resonance and Two-Dimensional Optical Imaging Spectroscopy

    The blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal is a biophysical consequence of the hemodynamic response to neuronal activity. Intrinsic optical imaging spectrosco...

    Aneurin J. Kennerley, Luke Boorman, Samuel Harris in Neurovascular Coupling Methods (2014)