-
Article
Open AccessBevacizumab plus octreotide and metronomic capecitabine in patients with metastatic well-to-moderately differentiated neuroendocrine tumors: the xelbevoct study
We assessed the activity and toxicity of the XELBEVOCT regimen in patients with metastatic well-to-moderately differentiated neuroendocrine neoplasms (WMD-NEN). Ancillary studies evaluated hypertension, protei...
-
Article
Prevalence of complementary/alternative medicines (CAMs) in a cancer population in northern Italy receiving antineoplastic treatments and relationship with quality of life and psychometric features
To explore the use of CAM (Complementary/Alternative Medicine) in a population of cancer patients undergoing antineoplastic therapy, and to compare differences in sociodemographics, quality of life, and psycho...
-
Article
Open AccessThe prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen
The purpose of the present study was to investigate the relationship of expression of hypoxia inducible factor (HIF)-1α-modifying enzymes prolyl hydroxylase (PHD)1, PHD2 and PHD3 to response of tumours and sur...
-
Chapter
Chemotherapy
The extreme rarity of adrenocortical carcinoma (ACC) has hampered the conduction of well-designed high-powered prospective studies testing the efficacy of systemic therapy. This limitation notwithstanding, the...
-
Article
Anti-angiogenic effect of tamoxifen combined with epirubicin in breast cancer patients
Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 2 (VEGFR2) are the key factors mediating neo-vascularization. They are often coexpressed in breast cancer. Sex ster...
-
Article
Restless legs syndrome and its relationship with anxiety, depression, and quality of life in cancer patients undergoing chemotherapy
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by uncomfortable and unpleasant sensations in the legs that are relieved by movement. This study evaluated the prevalence of RLS in ...
-
Article
Open AccessContinuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte Oncology Network
Well-differentiated neuroendocrine carcinomas are highly vascularized and may be sensitive to drugs administered on a metronomic schedule that has shown antiangiogenic properties. A phase II study was designed...
-
Article
Il trattamento del carcinoma del surrene
Il trattamento di elezione nei pazienti affetti da carcinoma del cortico-surrene (ACC) è rappresentato dalla chirurgia che ha un impatto favorevole sulla sopravvivenza globale. La diagnosi di ACC è tuttavia ra...
-
Article
Six-year stabilisation of a relapsed pelvic mass from rectal cancer after oxaliplatin-containing chemotherapy
Chemotherapy alone without a multimodality approach has never been demonstrated to cure metastatic colorectal cancer patients. We report the case of a young woman referred in 1999 to our institution for a pelv...
-
Article
Co-expression of EGF receptor, TGFα and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis
Autocrine tumour growth factor alpha (TGFα)/epidermal growth factor receptor (EGFR) stimulation in colorectal carcinoma (CRC) cells regulates cell adhesion and invasiveness via ribosomal protein S6 kinase (S6K...
-
Article
Prognostic significance of changes in CA 15-3 serum levels during chemotherapy in metastatic breast cancer patients
Tumor response to first-line chemotherapy in advanced breast cancer offers prognostic information and may be used as a surrogate marker for evaluating treatment efficacy. With this study we wanted to determine...
-
Article
Magnetic Resonance Imaging in Comparison to Clinical Palpation in Assessing the Response of Breast Cancer to Epirubicin Primary Chemotherapy
Purpose. To investigate whether magnetic resonance imaging (MRI) is superior to clinical palpation in the assessment of response of breast cancer to primary chemotherapy (PC).
-
Article
Background to and Management of Treatment-Related Bone Loss in Prostate Cancer
Prostate cancer is a common disease among older men. Androgen suppression by either orchiectomy or administration of luteinising hormone—releasing hormone (LHRH) analogues is the mainstay of treatment. Since t...
-
Article
Accuracy of mammography and echography versus clinical palpation in the assessment of response to primary chemotherapy in breast cancer patients with operable disease
The response to primary chemotherapy is an important prognostic factor in patients with non metastatic breast cancer. In this study we compared the assessment of response performed by clinical palpation to tha...
