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  1. Article

    Open Access

    Anti-plasmodial activity of Dicoma tomentosa (Asteraceae) and identification of urospermal A-15-O-acetate as the main active compound

    Natural products could play an important role in the challenge to discover new anti-malarial drugs. In a previous study, Dicoma tomentosa (Asteraceae) was selected for its promising anti-plasmodial activity after...

    Olivia Jansen, Monique Tits, Luc Angenot, Jean-Pierre Nicolas… in Malaria Journal (2012)

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    Article

    Discovery of a natural thiamine adenine nucleotide

    Lucien Bettendorff, Barbara Wirtzfeld, Alexander F Makarchikov… in Nature Chemical Biology (2007)

  3. Article

    Open Access

    Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats

    The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats.

    Nancy Garbacki, Monique Tits, Luc Angenot, Jacques Damas in BMC Pharmacology (2004)

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    Article

    Bisindole alkaloids from Strychnos guianensis are effective antagonists of nicotinic acetylcholine receptors in cultured human TE671 cells

    Several mono- and bisindole quaternary alkaloids isolated from the stem bark of Strychnos guianensis have recently been shown to be effective blockers of neuromuscular transmission in mice. In this study, we used...

    Pierre Wins, Ilca Margineanu… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2003)

  5. No Access

    Article

    Apoptosis induction in human cancer cells by sungucine from Strychnos icaja root

    Sungucine (SG) and isosungucine (ISG) are bisindole alkaloids characterized by a 5'-23 link between the two parts of the compounds, which are till now specific to Strychnos icaja. In this work, SG and ISG were su...

    Michel Frederich, Mohamed Bentires-Ali… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2003)

  6. No Access

    Article

    Effects of prodelphinidins isolated from Ribes nigrum on chondrocyte metabolism and COX activity

    Articular diseases, such as osteoarthritis, is the clinical expression of the loss of cartilage function. COX inhibitors are widely used in the treatment of such pathologies for their beneficial effects on in...

    Nancy Garbacki, Luc Angenot… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2002)