797 Result(s)

Article

Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress

Ronghua Fang, Jie Chen, Jiangchuan Long, Binghan Zhang, Qixuan Huang… in Biogerontology (2024)

Article

The influence of sex-specific factors on biological transformations and health outcomes in aging processes

The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The differences in sex chromosomes are fundamental to the presence of...

Yongyin Huang, Hongyu Li, Runyu Liang, Jia Chen, Qiang Tang in Biogerontology (2024)

Article

Neutrophil-derived migrasomes are an essential part of the coagulation system

Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist...

Dong Jiang, Lin Jiao, Qing Li, Renxiang **e, Haohao Jia, ShiHui Wang… in Nature Cell Biology (2024)

Article

Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3

KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how these mutations may shape epigenomic and transcrip...

Marco Seehawer, Zheqi Li, Jun Nishida, Pierre Foidart… in Nature Cell Biology (2024)

Article

Lipidomic signatures in patients with early-onset and late-onset Preeclampsia

Preeclampsia is a pregnancy-specific clinical syndrome and can be subdivided into early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) according to the gestational age of delivery. Patients with ...

Yu Huang, Qiaoqiao Sun, Beibei Zhou, Yiqun Peng, **gyun Li, Chunyan Li… in Metabolomics (2024)

Article

The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice

Helicase for meiosis 1 (HFM1), a putative DNA helicase expressed in germ-line cells, has been reported to be closely associated with premature ovarian insufficiency (POI). However, the underlying molecular mec...

Chenyi Zhong, Huiyuan Wang, **ong Yuan, Yuheng He, **g Cong… in Biological Research (2024)

Article

Electroacupuncture attenuates neuropathic pain via suppressing BIP-IRE-1α-mediated endoplasmic reticulum stress in the anterior cingulate cortex

Studies have suggested that endoplasmic reticulum stress (ERS) is involved in neurological dysfunction and that electroacupuncture (EA) attenuates neuropathic pain (NP) via undefined pathways. However, the rol...

Lin-Wei Ma, Yu-Fan Liu, Hui Zhang, Chang-Jun Huang, Ang Li… in Biological Research (2024)

Article

Lipidomics random forest algorithm of seminal plasma is a promising method for enhancing the diagnosis of necrozoospermia

Despite the clear clinical diagnostic criteria for necrozoospermia in andrology, the fundamental mechanisms underlying it remain elusive. This study aims to profile the lipid composition in seminal plasma syst...

Tianqin Deng, Wanxue Wang, Zhihong Fu, Yuli **e, Yonghong Zhou, Jiangbo Pu… in Metabolomics (2024)

Article

IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), are present in most gliomas. IDH1 mutation is an important prognostic marker in glioma. However, its regulatory mechanism in glioma remains incomplet...

Haiting Zhao, Li Meng, Peng Du, **nbin Liao, **n Mo, Mengqi Gong… in Biological Research (2024)

Article

Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis

The activated microglia have been reported as pillar factors in neuropathic pain (NP) pathology, but the molecules driving pain-inducible microglial activation require further exploration. In this study, we in...

Yinghao **ng, Pei Li, Yuanyuan Jia, Kexin Zhang, Ming Liu… in Biological Research (2024)

Article

Characterizing human postprandial metabolic response using multiway data analysis

Analysis of time-resolved postprandial metabolomics data can improve our understanding of the human metabolism by revealing similarities and differences in postprandial responses of individuals. Traditional da...

Shi Yan, Lu Li, David Horner, Parvaneh Ebrahimi, Bo Chawes… in Metabolomics (2024)

Article

Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters

Despite the record speed of develo** vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination and appl...

Binan Zhao, Haoran Peng, Yan**g Zhang, Jie Zhang, Desheng Kong… in Biological Research (2024)

Article

CD32 captures committed haemogenic endothelial cells during human embryonic development

During embryonic development, blood cells emerge from specialized endothelial cells, named haemogenic endothelial cells (HECs). As HECs are rare and only transiently found in early develo** embryos, it remai...

Rebecca Scarfò, Lauren N. Randolph, Monah Abou Alezz… in Nature Cell Biology (2024)

Article

4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara

Cardiac dysfunction after sepsis the most common and severe sepsis-related organ failure. The severity of cardiac damage in sepsis patients was positively associated to mortality. It is important to look for d...

Yuanqun Zhou, Yu Zhu, Yue Wu, **nming **ang, **ngnan Ouyang, Liangming Liu… in Metabolomics (2024)

Article

Correction: Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis

**aoting **, Qianbo Chen, Jia Ma, Xuewei Wang… in Journal of Molecular Histology (2024)

Article

Vitamin D₃ reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3

It has been reported that the effective inhibition of vascular endothelial growth factor (VEGF) can prevent the progression of ovarian hyperstimulation syndrome (OHSS). The present study aimed to investigate t...

Min** Zhang, Li Chen, Qun** Xu… in In Vitro Cellular & Developmental Biology … (2024)

Article

Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis

Diabetic retinopathy (DR) is a serious microvascular complication of diabetes. The aim of this study was to explore the effect of Sestrin2 on DR through the regulation of autophagy and ferroptosis levels and i...

**aoting **, Qianbo Chen, Jia Ma, Xuewei Wang… in Journal of Molecular Histology (2024)

Article

Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function

Endometrial fibrosis, a significant characteristic of intrauterine adhesion (IUA), is caused by the excessive differentiation and activation of endometrial stromal cells (ESCs). Glutaminolysis is the metabolic...

Pei Chen, Chaoshuang Ye, Yunke Huang, Bingning Xu, Tianyu Wu… in Biological Research (2024)

Article

Plasma and serum metabolic analysis of healthy adults shows characteristic profiles by subjects’ sex and age

Pre-analytical factors like sex, age, and blood processing methods introduce variability and bias, compromising data integrity, and thus deserve close attention.

Rui Xu, Shiqi Zhang, Jieli Li, Jiangjiang Zhu in Metabolomics (2024)

Article

Author Correction: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma

Dan Liao, Li Zhong, Junqiang Yin, Cuiling Zeng, **n Wang… in Nature Cell Biology (2024)