3,536 Result(s)

Article

RhoA-mediated G₁₂-G₁₃ signaling maintains muscle stem cell quiescence and prevents stem cell loss

Multiple processes control quiescence of muscle stem cells (MuSCs), which is instrumental to guarantee long-term replenishment of the stem cell pool. Here, we describe that the G-proteins G₁₂-G₁₃ integrate signal...

Yundong Peng, **g**g Du, Rui Li, Stefan Günther, Nina Wettschureck… in Cell Discovery (2024)

Article

IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages

In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlig...

Jiayu Zhang, Yu Dong, Shan Yu, Keshu Hu, Lingyun Zhang, Min **ong… in Cell Death & Disease (2024)

Article

Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway

Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...

Mi Lin, Ru-Hong Tu, Sheng-Ze Wu, Qing Zhong, Kai Weng, Yu-Kai Wu… in Cell Death & Disease (2024)

Article

Biological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma

The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant immune cells in tumor microenvironment and their function in tumo...

Deming Li, Ting Zhang, Ye Guo, Cong Bi, Ming Liu, Gang Wang in Cell Death & Disease (2024)

Article

Synthetic macrolides overcoming MLS_BK-resistant pathogens

Conventional macrolide-lincosamide-streptogramin B-ketolide (MLS_BK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...

Cong-Xuan Ma, Ye Li, Wen-Tian Liu, Yun Li, Fei Zhao, **ao-Tian Lian… in Cell Discovery (2024)

Article

Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells

Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such ...

Guangsheng Zhu, Yanan Wang, Yingjie Wang, Hua Huang, Boshi Li… in Cell Death & Disease (2024)

Article

SETD8 inhibits apoptosis and ferroptosis of Ewing’s sarcoma through YBX1/RAC3 axis

Ewing’s sarcoma (ES) represents a rare yet exceedingly aggressive neoplasm that poses a significant health risk to the pediatric and adolescent population. The clinical outcomes for individuals with relapsed o...

Huimou Chen, **g Hu, **lin **ong, Hongling Chen, Qiaofang Liao… in Cell Death & Disease (2024)

Article

Correction: Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Xuexia Zhou, Xuebing Li, Run Wang, Dan Hua, Cuiyun Sun, Lin Yu… in Cell Death & Disease (2024)

Article

Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation

Accumulating evidence suggests that caspase-3 plays critical roles beyond apoptosis, serving pro-survival functions in malignant transformation and tumorigenesis. However, the mechanism of non-apoptotic action...

Chenchen Zhu, Fushun Fan, Chuan-Yuan Li, Yan **ong, **njian Liu in Cell Death & Disease (2024)

Article

ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction

Z-DNA binding protein 1 (ZBP1) is a crucial player in the intracellular recognition of Z-form nucleic acids (Z-NAs) through its Zαβ domain, initiating downstream interactions with RIPK1 and RIPK3 via RHIM doma...

Feiyan **e, Di Wu, **g Huang, Xuehe Liu, Yanfang Shen… in Cell Death & Disease (2024)

Article

IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation

IL-17+ γδ T cells (γδ T17) are kick-starters of inflammation due to their strict immunosurveillance of xenobiotics or cellular damages and rapid response to pro-inflammatory stimulators. IL-27 is a well-recogn...

Mingyue Zhang, Dehai Li, **g Zhu, Xue **a, Hua Zhang, Jie Wu… in Cell Death & Disease (2024)

Article

Phase separation of RNF214 promotes the progression of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been obse...

Zheng-Jie He, Ke He, Song-Wang Cai, Rui Zhang, Zhong-Bao Shao… in Cell Death & Disease (2024)

Article

BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC

An increasing evidence supports that cell competition, a vital selection and quality control mechanism in multicellular organisms, is involved in tumorigenesis and development; however, the mechanistic contrib...

Sikai Wang, Hongxia Cheng, Miaomiao Li, Dongmei Gao, Haoran Wu… in Cell Death & Disease (2024)

Article

A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells

Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species are highly abundant and essential component of human cells, which often changed i...

Huanhuan Qin, Meixi Peng, **gsong Cheng, Zhenyu Wang, Yinghui Cui… in Cell Death & Disease (2024)

Article

Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer

Colorectal cancer (CRC) is one of the most common tumors of the digestive system worldwide. KRAS mutations limit the use of anti-EGFR antibodies in combination with chemotherapy for the treatment of CRC. There...

Ya-nan Zheng, Si-yue Lou, Jun Lu, Fan-li Zheng, Yong-mei Tang… in Cell Death & Disease (2024)

Article

Correction: Sorcin regulate pyroptosis by interacting with NLRP3 inflammasomes to facilitate the progression of hepatocellular carcinoma

Zhenfen Li, Ziyue Yang, Yuanyuan Zhu, Chunmeng Fu, Ning Li… in Cell Death & Disease (2024)

Article

Macrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury

Damage to renal tubular epithelial cells (RTECs) signaled the onset and progression of sepsis-associated acute kidney injury (SA-AKI). Recent research on mitochondria has revealed that mitophagy plays a crucia...

Tianlong Li, Jiachen Qu, Chang Hu, **g**g Pang, Yaoyao Qian… in Cell Death & Disease (2024)

Article

RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway

Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow transplantation and several hypomethylating agents. However, ...

Li Liu, Chaoying Yang, Lin Zhu, Yanyan Wang, Fuxiang Zheng… in Cell Death & Disease (2024)

Article

Pig blastocyst-like structure models from embryonic stem cells

Pluripotent stem cells have the potential to generate embryo models that can recapitulate developmental processes in vitro. Large animals such as pigs may also benefit from stem-cell-based embryo models for im...

**zhu **ang, Hanning Wang, Bingbo Shi, Jiajun Li, Dong Liu, Kaipeng Wang… in Cell Discovery (2024)

Article

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway

Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays a crucial role in the develo...

Wenqing Zou, Yiming Lei, Cong Ding, Hongjun **ao, Shunxin Wang… in Cell Death & Disease (2024)