-
Article
Open AccessBrown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosc...
-
Article
PS13 - 7. Plasma cholesteryl ester transfer protein: a biomarker for hepatic macrophages
Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from HDL to LDL and high CETP activity results in an atherogenic lipid phenotype. Thus, inhibiting CETP is a target for dyslipidemia treat...
-
Article
PS1 - 8. Brown adipose tissue volume is markedly lower in healthy lean adolescents from South Asian compared to white Caucasian origin
South Asians have a higher risk of develo** type 2 diabetes than white Caucasians. Though the underlying cause is still poorly understood, we recently found that South Asian adolescents have reduced resting ...
-
Article
PS1 - 5. The GLP-1 receptor agonist exendin-4 reduces atherosclerosis development and NASH in APOE*3.Leiden.CETP mice
The GLP-1 receptor agonist exendin-4 (ex-4) improves glucose intolerance and is currently being used in the treatment of type 2 diabetes mellitus.
-
Article
PS20 - 92. Inhibition of the central melanocortin system affects VLDL metabolism in E3L and E3L.CETP mice
The central melanocortin system is known to regulate food intake, adiposity, blood pressure, and glucose metabolism. Recently, it has been reported that the melanocortin system also regulates cholesterol metab...
-
Article
PS19 - 90. BMP-7 reduces high fat diet-induced adiposity in mice by activating brown adipose tissue in a sympathetic-dependent way: Implications for obesity
In mammals, two types of adipose tissue are present: white and brown. While the main function of white adipose tissue (WAT) is the storage of fat, brown adipose tissue (BAT) dissipates energy stored in triglyc...
-
Article
PS2 - 10. Constant light exposure disturbs circadian rhythm in energy metabolism and insulin sensitivity
Disturbances in circadian rhythm are associated with increased incidence of obesity and T2D. Here we examined the effect of a disturbed circadian rhythm on energy metabolism and insulin sensitivity by exposing...
-
Article
PS16 - 82. GLP-1 receptor agonism inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high fat diet-fed APOE*3-Leiden mice
Glucagon-like peptide 1 (GLP-1) receptor agonism has been demonstrated to improve glucose intolerance and exendin-4, a GLP-1 receptor agonist, is currently being used for the treatment of type 2 diabetes melli...
-
Article
PS8 - 44. FcR-γ-chain-/- mice are protected against diet-induced obesity and diet-induced insulin resistance
Obesity and its related metabolic disorders such as insulin resistance are associated with low-grade systemic inflammation. Recently it was found that B cells are also involved in induction of insulin resistan...
-
Article
Open AccessHigh levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity
Relatively little is known about the role of specific saturated fatty acids in the development of high fat diet induced obesity and insulin resistance. Here, we have studied the effect of stearate in high fat ...
-
Article
Open AccessPreoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery
Experimental models show that apolipoprotein CI (apoCI) binds and enhances the inflammatory response to endotoxin. We studied in patients undergoing cardiopulmonary bypass surgery (CPB) and experiencing endoto...
-
Article
Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis
We recently reported that apolipoprotein CI (apoCI) protects against the development of murine bacterial sepsis. We now examined the time course of plasma apoCI levels in survivors and non-survivors of severe ...
-
Article
Local Cre-Mediated Gene Recombination in Vascular Smooth Muscle Cells in Mice
Here we describe a means to conditionally modify genes at a predefined and localized region of the vasculature using a perivascular drug delivery device (PDD). A 4-hydroxytamoxifen (4-OHT)-eluting PDD was appl...
-
Article
Phenotype Characterisation Using Integrated Gene Transcript, Protein and Metabolite Profiling
Multifactorial diseases present a significant challenge for functional genomics. Owing to their multiple compartmental effects and complex biomolecular activities, such diseases cannot be adequately characteri...
-
Article
Intestinal lipid absorption is not affected in CD36 deficient mice
Increasing evidence has implicated the membrane protein CD36 (or fatty acid translocase, FAT) to be involved in high affinity fatty acid uptake. CD36 is expressed in tissues active in fatty acid metabolism, li...
-
Chapter
Intestinal lipid absorption is not affected in CD36 deficient mice
Increasing evidence has implicated the membrane protein CD36 (or fatty acid translocase, FAT) to be involved in high affinity fatty acid uptake. CD36 is expressed in tissues active in fatty acid metabolism, li...
-
Article
Effective generation of very low density lipoprotein receptor transgenic mice by overlap** genomic DNA fragments: high testis expression and disturbed spermatogenesis
The generation of functional transgenes via microinjection of overlap** DNA fragments has previously been reported to be successful, but it is still not a widely applied approach. Here we show that the metho...
-
Article
Mutational and genetic origin of LDL receptor gene mutations detected in both Belgian and Dutch familial hypercholesterolemics
DNA samples from 100 unrelated Belgian patients with familial hypercholesterolemia (FH) were screened for the presence of specific low-density lipoprotein receptor (LDLR) gene mutations, previously shown to b...
-
Chapter
Hyperlipidemia and Atherosclerosis in APOE Transgenic Mice
Patients with Familial Dysbetalipoproteinemia (FD) are characterized by elevated plasma levels of VLDL- and chylomicron-remnant lipoproteins concomitant with a strongly increased risk for atherosclerosis. Even...
-
Article
The T705I mutation of the low density lipoprotein receptor gene (FH Paris-9) does not cause familial hypercholesterolemia
Familial hypercholesterolemia (FH) is a genetic disease caused by mutations in the low-density lipoprotein receptor gene. Among the more than 200 mutations so far identified, the T705I substitution in exon 15...
