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Open AccessAptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer
Due to its complicated pathophysiology, propensity for metastasis, and poor prognosis, colon cancer is challenging to treat and must be managed with a combination of therapy. Using rolling circle transcription...
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Article
Sandwich capture ultrasensitive sensor based on biohybrid interface for the detection of Cronobacter sakazakii
A simple, rapid and ultrasensitive visual sensing method for the detection of Cronobacter sakazakii (C. sakazakii) based on a biohybrid interface was established. During the entire sensing process, quadruple-casc...
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Article
Fluorescent detection of Cu (II) ions based on DNAzymatic cascaded cyclic amplification
A fluorescent biosensor based on the cascaded cyclic amplification-lighted copper nanoparticles has been developed, optimized, and validated. In the double-modular cascaded cyclic amplification, a DNAzymatic c...
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Article
A colorimetric zinc(II) assay based on the use of hairpin DNAzyme recycling and a hemin/G-quadruplex lighted DNA nanoladder
A method is described for sensitive colorimetric determination of zinc(II) ions that uses (a) a Zn(II)-responsive hairpin DNAzyme that assists target recycling, (b) hybridization chain reaction, and (c) hemin/...
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Article
Colorimetric detection and ty** of E. coli lipopolysaccharides based on a dual aptamer-functionalized gold nanoparticle probe
A rapid method for identification and ty** of lipopolysaccharides (LPS) was developed by utilizing the different binding affinities between two kinds of gold nanoparticles (AuNPs) functionalized with two apt...
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Article
Open AccessA rapid and visual turn-off sensor for detecting copper (II) ion based on DNAzyme coupled with HCR-based HRP concatemers
To solve the requirement of on-site, rapid, and visual detection of copper (II) (Cu2+) in aqueous solution, a turn-off sensor for detecting copper (II) ion was developed based on Cu2+-dependent DNAzyme as the rec...
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Article
Open AccessHighly sensitive detection of lipopolysaccharides using an aptasensor based on hybridization chain reaction
Lipopolysaccharides (LPS), integral components of the outer membrane of all gram-negative bacteria, are closely associated with foodborne diseases such as fever, diarrhea and hypotension and thus, the early an...
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Article
Open AccessDevelopment of a double-antibody sandwich ELISA for rapid detection of Bacillus Cereus in food
Bacillus cereus is increasingly recognized as one of the major causes of food poisoning in the industrialized world. In this paper, we describe a sensitive double-antibody sandwich enzyme-linked immunosorbent ass...