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Article
Correction to: Improvement of recycled concrete aggregate using alkali-activated binder treatment
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Article
Improvement of recycled concrete aggregate using alkali-activated binder treatment
This paper presents a study on improving recycled concrete aggregate (RCA) using alkali-activated binder treatment for producing Portland cement concrete (PCC). The recycled concrete aggregate was treated with...
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Article
Dynamic Instability Analysis of Axially Compressed Castellated Columns
This paper presents an analytical study on the dynamic instability of castellated columns subjected to axial excitation loading. By assuming the instability modes, the kinetic energy and strain energy of the c...
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Article
Total body irradiation tremendously impair the proliferation, differentiation and chromosomal integrity of bone marrow-derived mesenchymal stromal stem cells
Total body irradiation (TBI) is frequently used in hematopoietic stem cell transplantation (HSCT) and is associated with many complications due to radiation injury to the normal cells, including normal stem ce...
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Article
Open AccessEZH2: novel therapeutic target for human cancer
Enhancer of Zeste homlog 2 (EZH2) is a catalytic subunit of epigenetic regulator Polycomb repressive complex 2 (PRC2), which trimethylates Lys 27 of histone H3, leading to silencing of the target genes that ar...
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Article
Free torsion of thin-walled structural members of open- and closed-sections
Free torsion of thin-walled structures of open- and closed-sections is a classical elastic mechanics problem, which, in literature, is often solved by the method of membrane analogy. The method of membrane ana...
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Article
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation
The argine methyltransferase PRMT5 methylates EGFR. This modification increases EGFR trans-autophosphorylation and attenuates ERK pathway activation.
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Article
CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells
The Polycomb group protein EZH2 promotes trimethylation of histone H3K27 and gene silencing. Cdk1 is found to phosphorylate EZH2 to inhibit its methyltransferase activity, affecting EZH2-target genes involved ...
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Article
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by directly interacting with and ph...
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Article
Tyrosine phosphorylation controls PCNA function through protein stability
The proliferating cell nuclear antigen (PCNA) is an essential protein for DNA replication and damage repair. How its function is controlled remains an important question. Here, we show that the chromatin-bound...
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Chapter and Conference Paper
NUMERICAL INVESTIGATION OF COUPLED TRANSPORT OF IONS AND IONIC SOLUTION IN CORNEA AND THEIR INFLUENCE ON CORNEAL HYDRATION
This paper presents a numerical study on the transport of ions and ionic solution in human corneas and their influences on the corneal hydration. The transport equations for ions and ionic solution within the ...
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Article
Determination of stability in nonlinear analysis of structures
This paper present a systematic study of the problems of structural nonlinear instability. Emphasis is on the treatment of coincident critical points and the development of available theory making it possible ...
