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Article
Tracking treatment effect heterogeneity in evolving environments
Heterogeneous treatment effect (HTE) estimation plays a crucial role in develo** personalized treatment plans across various applications. Conventional approaches assume that the observed data are independen...
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Article
Analysis of functional connectivity changes in attention networks and default mode networks in patients with depression and insomnia
Major Depressive Disorder (MDD) and Insomnia Disorder (ID) are prevalent psychiatric conditions often occurring concurrently, leading to substantial impairment in daily functioning. Understanding the neurobiol...
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Article
Open AccessDiscovery of gefitinib-1,2,3-triazole derivatives against lung cancer via inducing apoptosis and inhibiting the colony formation
A series of 20 novel gefitinib derivatives incorporating the 1,2,3-triazole moiety were designed and synthesized. The synthesized compounds were evaluated for their potential anticancer activity against EGFR w...
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Article
Open AccessUnraveling the relationship between high-sensitivity C-reactive protein and frailty: evidence from longitudinal cohort study and genetic analysis
This study aimed to investigate the association of high-sensitivity C-reactive protein (hs-CRP) with incident frailty as well as its effects on pre-frailty progression and regression among middle-aged and olde...
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Article
Achieving a remarkable low-temperature tensile ductility in a high-strength tungsten alloy
Hot-swaging yields a high ultimate tensile strength of 712 MPa but a limited tensile ductility with the total elongation of 3.6% at a testing temperature of 200 °C in a representative W-0.5wt.%ZrC alloy. In th...
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Article
Open AccessPresurgical computed tomography-guided localization of lung ground glass nodules: comparing hook-wire and indocyanine green
Presurgical computed tomography (CT)-guided localization is frequently employed to reduce the thoracotomy conversion rate, while increasing the rate of successful sublobar resection of ground glass nodules (GG...
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Article
( ±)-Dibrevianamides Q1 and Q2, the key precursors of asperginulin A from a marine-derived fungus
Two pairs of new dimeric diketopiperazine alkaloids, ( ±)-dibrevianamides Q1 and Q2 (( ±)-1 and ( ±)-2), together with seven previously reported analogues (( ±)-3, 4–6, and ( ±)-7) were obtained from a marine-der...
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Article
Open AccessRobot versus video-assisted thoracoscopic thymectomy for large thymic epithelial tumors: a propensity-matched analysis
Both video-assisted thoracoscopic surgery (VATS) thymectomy and robot-assisted thoracoscopic surgery (RATS) thymectomy have been suggested as technically sound approaches for early-stage thymic epithelial tumo...
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Article
An experimental study on RH vacuum chamber with a weir
A new Ruhrstahl–Heraeus (RH) equipment with a weir added to the vacuum chamber was designed to help improve refining efficiency of low-carbon steel production. The flow characteristics of the new RH equipment ...
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Article
Open AccessDiscovery of neddylation E2s inhibitors with therapeutic activity
Neddylation is the writing of monomers or polymers of neural precursor cells expressed developmentally down-regulated 8 (NEDD8) to substrate. For neddylation to occur, three enzymes are required: activators (E...
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Article
Open AccessEffects of multiple cations and sintering temperature on microstructure and dielectric properties in Na1/2Ln1/2Cu3Ti4O12 (Ln = Sm and Eu) ceramic materials
Na1/2Eu1/2Cu3Ti4O12 and Na1/2Sm1/2Cu3Ti4O12 dielectric ceramics were synthesized at different sintering temperatures (950, 975 and 1000 °C) by a solid-state reaction method. Phase structure, cation valence state,...
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Article
Li-ion transport in solid-state electrolyte of Li1–xAl1–xSi2+xO6: an ab initio study
All-solid-state batteries are considered as next-generation technology for energy storage due to their high energy density and excellent safety. However, only a few solid electrolytes exhibit ionic conductivit...
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Article
DRGN: a dynamically reconfigurable accelerator for graph neural networks
Graph neural networks (GNNs) have achieved great success in processing non-Euclidean geometric spatial data structures. However, the irregular memory access of aggregation and the power-law distribution of the...
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Article
A dual-switching spin-crossover framework with redox regulation and guest response
A dual-switching spin crossover metal-organic framework (SCO-MOF) [Fe(TPB){PtII(CN)4}]·3iPrOH·4H2O (TPB = 1,2,4,5-tetra(pyridin-4-yl)benzene) is developed via the combination of redox-active framework and tunable...
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Article
Open AccessComparison of lipid accumulation product and visceral adiposity index with traditional obesity indices in early-onset type 2 diabetes prediction: a cross-sectional study
The purpose of the study was to compare the efficacy of two novel obesity indices, lipid accumulation product (LAP) and visceral adiposity index (VAI), with traditional obesity indices in predicting early-onse...
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Article
Efficient Co-production of Docosahexaenoic Acid Oil and Carotenoids in Aurantiochytrium sp. Using a Light Intensity Gradient Strategy
Aurantiochytrium is a promising source of docosahexaenoic acid (DHA) and carotenoids, but their synthesis is influenced by environmental stress factors. In this study, the effect of different light intensities on...
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Advances in Potato Breeding for Abiotic Stress Tolerance
Potato is the third important food crop for global food security. To breed new varieties with stress tolerance, tuber yield and quality are a base for sustainable development of the potato industry. With clima...
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Article
Open AccessAnatomical type analysis of right interlobar artery based on chest thin-slice CT scan and three-dimensional reconstruction
To analyse and summarize branching pattern types of the interlobar portion of right pulmonary arteries (RPA) through chest thin-slice CT scans and three-dimensional reconstruction.
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Article
A Fundamental Role of Slope Aspect and Elevation in Controlling Diversity Patterns of Soil Bacterial Communities: Insights from an Arid-Montane Ecosystem in China
In montane ecosystems, slope aspect and elevation are the main topographic parameters that produce environmental heterogeneity related to microclimate, pedogenic processes, and vegetation patterns. However, th...
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Article
Clinical effects of cluster technology optimization and innovations on laparoscopic splenectomy and azygoportal disconnection: a single-center retrospective study with 500 consecutive cases
In Asia, laparoscopic splenectomy and azygoportal disconnection (LSD) has been widely regarded as a preferential treatment modality for cirrhotic portal hypertension (PH). However, LSD involves high surgical r...
