10 Result(s)

Article

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2...

Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou… in Nature Communications (2023)

Article

Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

ATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid metabolism. The physiological consequences as well as the molecular mechanisms orchestratin...

Alejandro Sola-García, María Ángeles Cáliz-Molina, Isabel Espadas… in Communications Biology (2023)

Article

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous stu...

Marie-Sophie Nguyen-Tu, Joseph Harris, Aida Martinez-Sanchez… in Diabetologia (2022)

Article

Author Correction: Intravital imaging of islet Ca²⁺ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou… in Nature Communications (2021)

Article

Intravital imaging of islet Ca²⁺ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are d...

Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou… in Nature Communications (2021)

Article

The pore-forming subunit MCU of the mitochondrial Ca²⁺ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca²⁺ uptake into pancreatic beta cell mitochondria potentiates or antagonises this process is still a matter o...

Eleni Georgiadou, Elizabeth Haythorne, Matthew T. Dickerson… in Diabetologia (2020)

Article

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still ha...

Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Noelia García Rodríguez… in Nature Communications (2018)

Article

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity

HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellit...

Jose M. Mellado-Gil, Esther Fuente-Martín, Petra I. Lorenzo… in Cell Death & Disease (2018)

Article

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, through the manipulation of molecular and cellular targets, would provide a means to counteract the deteri...

José Manuel Mellado-Gil, Carmen María Jiménez-Moreno… in Diabetologia (2016)

Article

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet

PAX4 is a key regulator of pancreatic islet development whilst in adult acute overexpression protects β-cells against stress-induced apoptosis and stimulates proliferation. Nonetheless, sustained PAX4 expressi...

Petra I. Lorenzo, Esther Fuente-Martín, Thierry Brun… in Scientific Reports (2015)