5 Result(s)
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Liubov S. Kalinichenko
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Article
Open AccessBehavioural effects of APH199, a selective dopamine D4 receptor agonist, in animal models
The dopamine D4 receptors (DRD4) play a key role in numerous brain functions and are involved in the pathogenesis of various psychiatric disorders. DRD4 ligands have been shown to moderate anxiety, reward and ...
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Article
Open AccessNeutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum ...
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Article
Open AccessNeutral ceramidase is a marker for cognitive performance in rats and monkeys
Ceramides are lipid molecules determining cell integrity and intercellular signaling, and thus, involved in the pathogenesis of several psychiatric and neurodegenerative disorders. However, little is known abo...
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Article
The role of sphingolipids in psychoactive drug use and addiction
Psychoactive drug use is a common behavior in many societies worldwide, frequently associated with drug instrumentalization. Regular use may develop into drug addiction, which is a severe psychiatric disorder ...
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Article
Open AccessParadoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis
Alcohol is a widely consumed drug that can lead to addiction and severe brain damage. However, alcohol is also used as self-medication for psychiatric problems, such as depression, frequently resulting in depr...
