9 Result(s)
within
Lisa Rein-Fischboeck
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Article
Open AccessHepatocyte expressed chemerin-156 does not protect from experimental non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is a rapidly growing liver disease. The chemoattractant chemerin is abundant in hepatocytes, and hepatocyte expressed prochemerin protected from NASH. Prochemerin is inacti...
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Article
Open AccessAccumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice
Dysregulated lipid metabolism is critically involved in the development of hepatocellular carcinoma (HCC). The respective metabolic pathways affected in HCC can be identified using suitable experimental models...
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Article
Open AccessHepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease
Emerging data support a role for lipids in non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in humans. With experimental models such data can be challenged or validated. Mice fed a low-m...
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Open AccessVariations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities
Non-alcoholic steatohepatitis (NASH) is a common disease and feeding mice a methionine-choline-deficient (MCD) diet is a frequently used model to study its pathophysiology. Genetic and environmental factors in...
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Article
The utrophin–beta 2 syntrophin complex regulates adipocyte lipid droplet size independent of adipogenesis
Utrophin is a widely expressed cytoskeleton protein and is associated with lipid droplets (LDs) in adipocytes. The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct me...
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Article
Alpha-syntrophin dependent expression of tubulin alpha 8 protein in hepatocytes
The scaffold protein alpha-syntrophin (SNTA) is a component of the dystrophin glycoprotein complex and has been comprehensively studied in skeletal muscle and adipocytes. SNTA is further expressed in the liver...
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Article
Circulating fibroblast growth factor 21 in patients with liver cirrhosis
Fibroblast growth factor 21 (FGF21) is an adipokine and hepatokine, and its hepatic expression is induced in the injured liver. Adiponectin, whose systemic levels are positively correlated with measures of hep...
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Article
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes
Tubulin alpha 8 (TUBA8) is highly abundant in murine liver tumors suggesting a role in hepatocellular carcinoma (HCC). Non-alcoholic steatohepatitis (NASH) is a risk factor for HCC. In mice that are fed with a...
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Article
Annexin A6 protein is downregulated in human hepatocellular carcinoma
Annexin A6 (AnxA6) is a lipid-binding protein highly expressed in the liver, regulating cholesterol homeostasis and signaling pathways with a role in liver physiology. Here, we analyzed whether hepatic AnxA6 l...
