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  1. Article

    Diabetes mellitus impairs circulating proangiogenic granulocytes

    Cardiovascular risk in diabetes is at least in part attributable to defective angiogenesis. Since diabetes negatively affects blood cells involved in angiogenesis, we herein evaluated whether diabetes impairs ...

    Roberta Cappellari, Marianna D’Anna, Lisa Menegazzo, Benedetta Maria Bonora… in Diabetologia (2020)

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    Article

    The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

    Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in t...

    Lisa Menegazzo, Valentina Scattolini, Roberta Cappellari… in Acta Diabetologica (2018)

  3. Article

    p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans

    Oxygen radicals generated by p66Shc drive adipogenesis, but contradictory data exist on the role of p66Shc in the development of obesity and the metabolic syndrome. We herein explored the relationships among p...

    Stefano Ciciliot, Mattia Albiero, Lisa Menegazzo, Nicol Poncina… in Diabetologia (2015)

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    Article

    NETosis is induced by high glucose and associated with type 2 diabetes

    The role of neutrophils in diabetes and its complications is unclear. Upon challenge with microbes and inflammatory triggers, neutrophils release enzymes and nuclear material, forming neutrophils extracellular...

    Lisa Menegazzo, Stefano Ciciliot, Nicol Poncina, Marta Mazzucato… in Acta Diabetologica (2015)

  5. Article

    Open Access

    The dipeptidyl peptidase-4 inhibitor Saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients

    Type 2 diabetes (T2D) is associated with reduction and dysfunction of circulating pro-angiogenic cells (PACs). DPP-4 inhibitors, a class of oral agents for T2D, might possess pleiotropic vasculoprotective acti...

    Nicol Poncina, Mattia Albiero, Lisa Menegazzo… in Cardiovascular Diabetology (2014)

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    Article

    Myeloid calcifying cells promote atherosclerotic calcification via paracrine activity and allograft inflammatory factor-1 overexpression

    Several cell types contribute to atherosclerotic calcification. Myeloid calcifying cells (MCCs) are monocytes expressing osteocalcin (OC) and bone alkaline phosphatase (BAP). Herein, we tested whether MCCs pro...

    Mattia Albiero, Marcello Rattazzi, Lisa Menegazzo… in Basic Research in Cardiology (2013)

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    Article

    Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy

    Bone marrow (BM) derived stem and progenitor cells contribute to cardiovascular homeostasis and are affected by cardiovascular risk factors. We devised a clinical data-driven approach to test candidate stem ce...

    Gian Paolo Fadini, Mattia Albiero, Florian Seeger… in Basic Research in Cardiology (2012)