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Article
Open AccessAnosognosia in hoarding disorder is predicted by alterations in cognitive and inhibitory control
Insight impairment contributes significantly to morbidity in psychiatric disorders. The neurologic concept of anosognosia, reflecting deficits in metacognitive awareness of illness, is increasingly understood ...
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Article
Open AccessDivergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections
Active avoidance behavior, in which an animal performs an action to avoid a stressor, is crucial for survival and may provide insight into avoidance behaviors seen in anxiety disorders. Active avoidance requir...
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Article
Open AccessMeasuring maladaptive avoidance: from animal models to clinical anxiety
Avoiding stimuli that predict danger is required for survival. However, avoidance can become maladaptive in individuals who overestimate threat and thus avoid safe situations as well as dangerous ones. Excessi...
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Article
Open AccessKetamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice
Obsessive-Compulsive Disorder (OCD), characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto-striatal circuits. There are currently no ...
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Article
Basomedial amygdala mediates top-down control of anxiety and fear
Activation of the ventral medial prefrontal cortex–basomedial amygdala pathway is shown to suppress anxiety and fear-related freezing in mice, thus identifying the basomedial amygdala (and not intercalated cel...
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Article
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Specific manipulation of midbrain dopamine neurons in freely moving rodents shows that their inhibition or excitation immediately modulates depression-like phenotypes that are induced by chronic mild stress, a...
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Article
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins
In this Analysis, the authors directly experimentally compare microbial opsins used for the control of neural activity. They extract essential principles and key parameters that can help end users with the des...
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Article
Optetrode: a multichannel readout for optogenetic control in freely moving mice
The authors describe the design of an optetrode, a device that allows for colocalized multi-tetrode electrophysiological recording and optical stimulation in freely moving mice.
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Article
Ultrafast optogenetic control
Channelrhodopsins such as ChR2 can drive spiking with millisecond precision. However, when ChR2 is highly expressed, a single light pulse can produce extra spikes, and ChR2 does not allow sustained spike train...
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Article
Open AccessColocalization of connexin 36 and corticotropin-releasing hormone in the mouse brain
Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in n...
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Article
Bi-stable neural state switches
Transgenic expression of microbial channelrhodopsins in neurons allows direct light activation of ionic currents. Here, the authors describe a modified channelrhodopsin that remains open for seconds once it is...
