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    Article

    Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer

    Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors worldwide. Immune checkpoint therapies (ICTs) have been proven to be a reliable treatment for some subtypes of CRC. Gut mic...

    Linsen Shi, Yumei Xu, Min Feng in Digestive Diseases and Sciences (2023)

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    Article

    The adenosine-A2a receptor regulates the radioresistance of gastric cancer via PI3K-AKT-mTOR pathway

    Radiotherapy is a key strategy in gastric cancer (GC) treatment. However, radioresistance remains a serious concern. It is unclear whether the accumulation of adenosine A2a receptor (ADO-A2aR) is related to ra...

    Guihong Liu, Song Yang, Yang Liu, Yumei Xu in International Journal of Clinical Oncology (2022)

  3. Article

    Open Access

    CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

    Accumulating studies have revealed that aberrant expression of circular RNAs (circRNAs) is widely involved in the tumorigenesis and progression of malignant cancers, including colorectal cancer (CRC). Neverthe...

    Tao Jiang, Hongyu Wang, Lianyu Liu, Hu Song, Yi Zhang, Jiaqi Wang in Molecular Cancer (2021)