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  1. No Access

    Article

    Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer

    Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors worldwide. Immune checkpoint therapies (ICTs) have been proven to be a reliable treatment for some subtypes of CRC. Gut mic...

    Linsen Shi, Yumei Xu, Min Feng in Digestive Diseases and Sciences (2023)

  2. Article

    Open Access

    Comprehensive surgical treatment for obstructive rectal endometriosis: a case report and review of the literature

    Intestinal obstruction caused by endometriosis maybe easily misdiagnosed as a tumor or other occupying disease in emergency condition. How to deal with it depending on the clarity of the preoperative diagnosis...

    Yumei Xu, Yixin Xu, Lu Miao, Meng Cao, Wei Xu, Linsen Shi in BMC Women's Health (2022)

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  3. No Access

    Article

    The adenosine-A2a receptor regulates the radioresistance of gastric cancer via PI3K-AKT-mTOR pathway

    Radiotherapy is a key strategy in gastric cancer (GC) treatment. However, radioresistance remains a serious concern. It is unclear whether the accumulation of adenosine A2a receptor (ADO-A2aR) is related to ra...

    Guihong Liu, Song Yang, Yang Liu, Yumei Xu… in International Journal of Clinical Oncology (2022)

  4. Article

    Open Access

    CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

    Accumulating studies have revealed that aberrant expression of circular RNAs (circRNAs) is widely involved in the tumorigenesis and progression of malignant cancers, including colorectal cancer (CRC). Neverthe...

    Tao Jiang, Hongyu Wang, Lianyu Liu, Hu Song, Yi Zhang, Jiaqi Wang… in Molecular Cancer (2021)

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  5. No Access

    Article

    Intralymph Node Expressions of A2AR and PD-L1 Were Associated with Metastasis and a Poor Prognosis in Gastric Cancer

    Lymph node metastasis is an independent risk factor for survival of gastric cancer, but the underlying mechanism remains unclear. Adenosine (ADO) plays an immune regulation role through binding to adenosine re...

    Linsen Shi, Zhaoying Wu, Hu Song, Wei Xu, Yixin Xu, Lin Yang… in Indian Journal of Surgery (2021)

  6. Article

    Open Access

    NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR

    Anoikis is a type of programmed cell death induced by detachment from the extracellular matrix. In cancer cells, anoikis resistance is essential for cancer cell survival in blood circulation and distant metast...

    Shangce Du, Ji Miao, Zhouting Zhu, En Xu, Linsen Shi, Shichao Ai… in Cell Death & Disease (2018)

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  7. No Access

    Article

    Preserving Duodenal-Jejunal (Foregut) Transit Does Not Impair Glucose Tolerance and Diabetes Remission Following Gastric Bypass in Type 2 Diabetes Sprague-Dawley Rat Model

    Possible mechanisms underlying diabetes remission following Roux-en-Y gastric bypass (RYGB) include eradication of putative factor(s) with duodenal-jejunal bypass.

    Ponnie R. Dolo, Libin Yao, Chao Li, **aocheng Zhu, Linsen Shi… in Obesity Surgery (2018)

  8. No Access

    Article

    Delayed presentation of uterine rupture in a didelphys uterus misdiagnosed as appendicitis: a case report and review of the literature

    Uterine rupture during pregnancy caused by uterine dysplasia, such as the double uterus, is very rare and easily overlooked by the surgeon.

    Linsen Shi, **aoman Lin, Suoyou Sha, Libin Yao… in Archives of Gynecology and Obstetrics (2017)