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  1. Article

    Open Access

    AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

    Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic resistance. Present study employed multi-omics, including phosphoproteomics, untargeted metabolomics and li...

    Jie Chen, Lingyuan Zhang, Yuheng Zhu, Di Zhao… in Signal Transduction and Targeted Therapy (2024)

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  2. Article

    Open Access

    Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells

    Reactive oxygen species (ROS) localized at the precise subcellular compartments are essential for regulating the activity of signaling proteins. Furthermore, ROS are master regulators of tumor malignant progre...

    Jie Chen, Yan Wang, Weimin Zhang, Di Zhao… in Signal Transduction and Targeted Therapy (2020)

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