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  1. Article

    Open Access

    AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

    Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic resistance. Present study employed multi-omics, including phosphoproteomics, untargeted metabolomics and li...

    Jie Chen, Lingyuan Zhang, Yuheng Zhu, Di Zhao… in Signal Transduction and Targeted Therapy (2024)

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  2. Article

    Open Access

    Surgery-induced gut microbial dysbiosis promotes cognitive impairment via regulation of intestinal function and the metabolite palmitic amide

    Perioperative neurocognitive disorders (PND) are the most common postoperative complications with few therapeutic options. Gut microbial dysbiosis is associated with neurological diseases; however, the mechani...

    Cailong Pan, Huiwen Zhang, Lingyuan Zhang, Lu Chen, Lu Xu, Ning Xu, Xue Liu… in Microbiome (2023)

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  3. No Access

    Article

    A Tri-Training method for lithofacies identification under scarce labeled logging data

    Lithofacies identification is critical to energy exploration and reservoir evaluation. Machine learning provides a way to use logging data for lithofacies intelligence identification. However, labeled logging ...

    **nyi Zhu, Hongbing Zhang, Quan Ren, Dailu Zhang, Fanxing Zeng… in Earth Science Informatics (2023)

  4. No Access

    Article

    Src heterodimerically activates Lyn or Fyn to serve as targets for the diagnosis and treatment of esophageal squamous cell carcinoma

    Although Src is one of the oldest and most investigated oncoproteins, its function in tumor malignancy remains to be defined further. In this study, we demonstrated that the inhibition of Src activity by ponat...

    **g Zhang, Di Zhao, Lingyuan Zhang, Yuanfan **ao… in Science China Life Sciences (2023)

  5. Article

    Open Access

    Tumor-associated macrophage (TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma (ESCC)

    Tumor cell dependence on activated oncogenes is considered a therapeutic target, but protumorigenic microenvironment-mediated cellular addiction to specific oncogenic signaling molecules remains to be further ...

    Jie Chen, Di Zhao, Lingyuan Zhang, **g Zhang… in Cellular & Molecular Immunology (2022)

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  6. Article

    Open Access

    Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells

    Reactive oxygen species (ROS) localized at the precise subcellular compartments are essential for regulating the activity of signaling proteins. Furthermore, ROS are master regulators of tumor malignant progre...

    Jie Chen, Yan Wang, Weimin Zhang, Di Zhao… in Signal Transduction and Targeted Therapy (2020)

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  7. Article

    Open Access

    Association between the traditional Chinese medicine pathological factors of opioid addiction and DRD2/ANKK1 TaqIA polymorphisms

    As we known, Traditional Chinese Medicine (TCM) helps to prevent the relapse of drug addiction. However, the scientific basis of TCM remains unclear because of limitations of current reductionist approaches. W...

    Meimei Cai, Zhiyang Su, Hong Zou, Qin Zhang… in BMC Complementary and Alternative Medicine (2015)

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