19 Result(s)

Article

Regulated cell death in hypoxic-ischaemic encephalopathy: recent development and mechanistic overview

Hypoxic-ischaemic encephalopathy (HIE) in termed infants remains a significant cause of morbidity and mortality worldwide despite the introduction of therapeutic hypothermia. Depending on the cell type, cellul...

Lingzhi Wu, Enqiang Chang, Hailin Zhao, Daqing Ma in Cell Death Discovery (2024)

Article

Regulated cell death and inflammasome activation in gut injury following traumatic surgery in vitro and in vivo: implication for postoperative death due to multiorgan dysfunction

Postoperative multi-organ dysfunction (MOD) is associated with significant mortality and morbidity. Necroptosis has been implicated in different types of solid organ injury; however, the mechanisms linking nec...

Lingzhi Wu, Hailin Zhao, Mengxu Zhang, Qizhe Sun, Enqiang Chang… in Cell Death Discovery (2023)

Article

The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence

Anaesthetics may modify colorectal cancer cell biology which potentially affects long-term survival. This study aims to compare propofol and sevoflurane regarding with the direct anaesthetic effects on cancer ...

Masae Iwasaki, Hailin Zhao, Cong Hu, Junichi Saito… in Cell Biology and Toxicology (2023)

Article

Cloud-native-based flexible value generation mechanism of public health platform using machine learning

Public health machinery learning platform based on cloud-native is a system platform that combines machine learning frameworks and cloud-native technology for public health services. The problem of how its fle...

Ming Jiang, Lingzhi Wu, Liming Lin, Qiaozhi Xu… in Neural Computing and Applications (2023)

Article

Identification of a class of potent USP25/28 inhibitors with broad-spectrum anti-cancer activity

** Peng, Kun Jiang, **ao Sun, Lingzhi Wu… in Signal Transduction and Targeted Therapy (2022)

Article

Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Immunoglobulin A nephropathy (IgAN) is identified as mesangial IgA deposition and is usually accompanied by other immunofluorescence deposits. The impact of immunofluorescent features in IgAN patients, however...

Lingzhi Wu, Di Liu, Ming **a, Guochun Chen, Yu Liu, Xue**g Zhu, Hong Liu in BMC Nephrology (2021)

Article

The Role of Neutrophil NETosis in Organ Injury: Novel Inflammatory Cell Death Mechanisms

NETosis is a type of regulated cell death dependent on the formation of neutrophil extracellular traps (NET), where net-like structures of decondensed chromatin and proteases are produced by polymorphonuclear ...

Zhen Cahilog, Hailin Zhao, Lingzhi Wu, Azeem Alam, Shiori Eguchi, Hao Weng… in Inflammation (2020)

Article

Coagulation parameters are associated with the prognosis of immunoglobulin a nephropathy: a retrospective study

Interstitial fibrosis/tubular atrophy (T) score is a known determinant of the progression of immunoglobulin A nephropathy (IgAN). Strong evidence indicates that the components of the coagulation system closely...

Ming **a, Di Liu, Liang Peng, Yan Li, Haiyang Liu, Lingzhi Wu… in BMC Nephrology (2020)

Article

Lasting effects of general anesthetics on the brain in the young and elderly: “mixed picture” of neurotoxicity, neuroprotection and cognitive impairment

General anesthetics are commonly used in major surgery. To achieve the depth of anesthesia for surgery, patients are being subjected to a variety of general anesthetics, alone or in combination. It has been lo...

Lingzhi Wu, Hailin Zhao, Hao Weng, Daqing Ma in Journal of Anesthesia (2019)

Article

Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis

Sepsis is life-threatening and often leads to acute brain damage. Dexmedetomidine, an α₂-adrenoceptor agonist, has been reported to possess neuroprotective effects against various brain injury but underlying mech...

Yi-Bing Sun, Hailin Zhao, Dong-Liang Mu, Wenwen Zhang, Jiang Cui… in Cell Death & Disease (2019)

Article

Both Bupivacaine and Levobupivacaine inhibit colon cancer cell growth but not melanoma cells in vitro

Retrospective studies indicate that the use of regional anaesthesia causes a reduction in cancer recurrence after oncological surgery, which could be due to anaesthetic’s negating effect on immunosuppression r...

Tianci Li, Lin Chen, Hailin Zhao, Lingzhi Wu, Joe Masters… in Journal of Anesthesia (2019)

Article

Electrically facilitated translocation of protein through solid nanopore

Nanopores have been proven as versatile single-molecule sensors for individual unlabeled biopolymer detection and characterization. In the present work, a relative large nanopore with a diameter of about 60 nm...

Lingzhi Wu, Hang Liu, Wenyuan Zhao, Lei Wang, Chuanrong Hou… in Nanoscale Research Letters (2014)

Article

Thermodynamical properties of protein kinase with adenine inhibitors

The protein-based molecular recognition of the adenine ring is essential to understand protein function and drug design as well. In this paper, a variety of the adenine-based inhibitors with modified groups of...

LingZhi Wu, Dong Hu, LiHua Tang, **aoFei Hu, Meng Qin in Chinese Science Bulletin (2013)