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  1. Article

    Open Access

    Artificial intelligence to guide precision anticancer therapy with multitargeted kinase inhibitors

    Vast amounts of rapidly accumulating biological data related to cancer and a remarkable progress in the field of artificial intelligence (AI) have paved the way for precision oncology. Our recent contribution ...

    Manali Singha, Limeng Pu, Brent A. Stanfield, Ifeanyi K. Uche in BMC Cancer (2022)

  2. Article

    Open Access

    An integrated network representation of multiple cancer-specific data for graph-based machine learning

    Genomic profiles of cancer cells provide valuable information on genetic alterations in cancer. Several recent studies employed these data to predict the response of cancer cell lines to drug treatment. Noneth...

    Limeng Pu, Manali Singha, Hsiao-Chun Wu in npj Systems Biology and Applications (2022)

  3. Article

    Open Access

    GraphDTI: A robust deep learning predictor of drug-target interactions from multiple heterogeneous data

    Traditional techniques to identify macromolecular targets for drugs utilize solely the information on a query drug and a putative target. Nonetheless, the mechanisms of action of many drugs depend not only on...

    Guannan Liu, Manali Singha, Limeng Pu, Prasanga Neupane in Journal of Cheminformatics (2021)

  4. Article

    Open Access

    eToxPred: a machine learning-based approach to estimate the toxicity of drug candidates

    The efficiency of drug development defined as a number of successfully launched new pharmaceuticals normalized by financial investments has significantly declined. Nonetheless, recent advances in high-throughp...

    Limeng Pu, Misagh Naderi, Tairan Liu, Hsiao-Chun Wu in BMC Pharmacology and Toxicology (2019)

  5. No Access

    Article

    Novel tailoring algorithm for abrupt motion artifact removal in photoplethysmogram signals

    Photoplethysmogram (PPG) signals are widely used for wearable electronic devices nowadays. The PPG signal is extremely sensitive to the motion artifacts (MAs) caused by the subject’s movement. The detection an...

    Limeng Pu, Pedro J. Chacon, Hsiao-Chun Wu, **-Woo Choi in Biomedical Engineering Letters (2017)