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Article
Open AccessImpaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model
Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some patients also experience autonomic dysfunction, anxiety, de...
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Article
Open AccessLong non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b
The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely elusive. Long non-coding RNAs (lncRNAs) have emerged as essential cell fate regulators. Here we found LncKd...
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Article
Enhancement of T Follicular Helper Cell-Mediated Humoral Immunity Reponses During Development of Experimental Autoimmune Myasthenia Gravis
Myasthenia gravis (MG) is a prototypical antibody-mediated neurological autoimmune disease with the involvement of humoral immune responses in its pathogenesis. T follicular helper (Tfh) cells have been implic...
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Article
Open AccessExcess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia
High salt diet (HSD) is one of the most important risk factors that contribute to many vascular diseases including ischemic stroke. One proposed mechanism underlying the disruption of blood-brain barrier (BBB)...
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Article
Supersolvability and Freeness for \(\psi \) -Graphical Arrangements
Let \(G\) G be ...
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Article
Bone Marrow Stromal Cells Inhibit the Activation of Liver Cirrhotic Fat-Storing Cells via Adrenomedullin Secretion
Cirrhosis, or liver fibrosis, which is mainly triggered by cirrhosis fat-storing cells (CFSCs) activation, has traditionally been considered an irreversible disease. However, recent observations indicate that ...
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Article
Open AccessAccumulation of natural killer cells in ischemic brain tissues and the chemotactic effect of IP-10
Stroke is accompanied by a distinguished inflammatory reaction that is initiated by the infiltration of immunocytes, expression of cytokines, and other inflammatory mediators. As natural killer cells (NK cells...
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Article
Pseudomonas aeruginosa: Mannose Sensitive Hemagglutinin Inhibits the Growth of Human Hepatocarcinoma Cells via Mannose-Mediated Apoptosis
A vaccine derived from the outer membrane proteins of the Gram-negative bacterium Pseudomonas aeruginosa has been shown to have immune modulatory properties. An inactivated mutant strain of P. aeruginosa with man...
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Article
Bone Marrow Stromal Cells Control the Growth of Hepatic Stellate Cells in vitro
Liver cirrhosis is characterized by hepatic dysfunction, with extensive accumulation of fibrous tissue in the liver. Hepatic stellate cells (HSCs) are the major source of fibrillar matrix proteins and play an ...
