-
Article
A Bifunctional-Blocker-Aided Hybridization Chain Reaction Lighting-Up Self-calibrating Nanocluster Fluorescence for Reliable Nucleic Acid Detection
In this work, we proposed a ratiometric silver nanoclusters (AgNCs) fluorescent assay by designing a bifunctional-blocker-aided hybridization chain reaction (HCR). Hairpin probe 1 (HP1) containing two special ...
-
Article
Open AccessEffect of Intraorbital Mechanical Compression on Retinal Microvascular Perfusion in Quiescent Thyroid-Associated Ophthalmopathy Based on Ocular Biomechanics Measured by Corvis ST
To analyze the correlation between orbital compliance and retinal vessel density (VD) based on dynamic Scheimpflug analyzer (Corvis ST) and optical coherence tomographic angiography (OCT-A).
-
Article
Open Access4D label-free proteomics analysis of oxygen-induced retinopathy with or without anti-VEGF treatment
Oxygen-induced retinopathy (OIR) animal model is widely used for retinopathy of prematurity (ROP) researches. The purpose of this study was to identify proteins and related pathways of OIR with or without anti...
-
Article
Open AccessNo side effects on rabbit retina or vitreous microenvironment by nd:YAG laser vitreolysis
To explore the safety of Neodymium:Yttrium-aluminum-garnet (Nd:YAG) laser vitreolysis based on the histological examination of the retina and the alteration of vitreous cytokines in the rabbits.
-
Article
An energy efficiency assessment of Yttrium–aluminum-garnet laser in vitro
To study the effect range of the Nd:YAG laser through various levels of cloudy medium for targets with varying grayscale values in vitro. The coated paper cards with grayscale values of 0, 50, 100, and 150 wer...
-
Article
Geochemical Characteristics of the Upper Permian Shales in the Central Nanpanjiang Basin: Implications for Paleoenvironment Conditions
Sedimentary environment can be restored qualitatively or semi-qualitatively by using elements or element combinations that are sensitive to paleoenvironment conditions. By measuring the major elements, trace e...
-
Article
Open AccessMyopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy
To compare the recurrence of myopic choroidal neovascularization (mCNV) based on the neovascular signal of mCNV around the perforating scleral vessel (PSV).
-
Article
Open AccessThe performance of a deep learning system in assisting junior ophthalmologists in diagnosing 13 major fundus diseases: a prospective multi-center clinical trial
Artificial intelligence (AI)-based diagnostic systems have been reported to improve fundus disease screening in previous studies. This multicenter prospective self-controlled clinical trial aims to evaluate th...
-
Article
Open AccessLong-Term Quantitative Analysis of Inner Retinal Dimples and Visual Function Post Internal Limiting Membrane Peeling in Macular Diseases
Inner retinal dimples (IRDs) are frequently detected after internal limiting membrane (ILM) peeling. However, the distribution of IRDs and its effect on postoperative visual function remain unclear. We aim to ...
-
Article
Open AccessOIMHS: An Optical Coherence Tomography Image Dataset Based on Macular Hole Manual Segmentation
Macular holes, one of the most common macular diseases, require timely treatment. The morphological changes on optical coherence tomography (OCT) images provided an opportunity for direct observation of the di...
-
Article
Open AccessVision degrading myodesopsia assessed with optos ultra-widefield scanning laser ophthalmoscope
To investigate the diagnostic sensitivity of Optos imaging for vision degrading myodesopsia (VDM).
-
Article
Open AccessArtificial Intelligence-Based Quantification of Central Macular Fluid Volume and VA Prediction for Diabetic Macular Edema Using OCT Images
We studied the correlation of central macular fluid volume (CMFV) and central subfield thickness (CST) with best-corrected visual acuity (BCVA) in treatment-naïve eyes with diabetic macular edema (DME) 1 month...
-
Article
Open AccessThe gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury
Approximately 60–80% of cancer patients treated with abdominopelvic radiotherapy suffer post-radiotherapy toxicities including radiation enteropathy and myelosuppression. Effective preventive and therapeutic s...
-
Article
Quantitative evaluation of dissociated optic nerve fibre layer (DONFL) following idiopathic macular hole surgery
To quantitatively evaluate concentric macular dark spots (CMDS) on spectral-domain optical coherence tomography (SD-OCT) to determine the morphological characteristics of dissociated optic nerve fibre layer (D...
-
Article
Open AccessNewly developed 3D in vitro models to study tumor–immune interaction
Immunotherapy as a rapidly develo** therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools consider...
-
Article
Screening of idiopathic epiretinal membrane using fundus images combined with blood oxygen saturation and vascular morphological features
To achieve an accurate diagnosis of idiopathic epiretinal membrane (iERM) through analyzing retinal blood vessel oxygen saturation (SO2) and vascular morphological features in fundus images.
-
Article
Open AccessShort-term postoperative changes in the choroidal vascularity index in patients with a unilateral epiretinal membrane
To investigate short-term choroidal structural and vascular changes after epiretinal membrane (ERM) surgery.
-
Article
Open AccessThe satisfaction with radiology residency training in China: results of a nationwide survey
National data on the satisfaction of radiology residents enrolled in standardized residency training (SRT) are rather scarce in China. This study identified a set of potential factors concerning SRT satisfacti...
-
Article
Open AccessJoint reconstruction of neuron and ultrastructure via connectivity consensus in electron microscope volumes
Nanoscale connectomics, which aims to map the fine connections between neurons with synaptic-level detail, has attracted increasing attention in recent years. Currently, the automated reconstruction algorithms...
-
Article
Open AccessYY1 promotes pancreatic cancer cell proliferation by enhancing mitochondrial respiration
KRAS-driven metabolic reprogramming is a known peculiarity features of pancreatic ductal adenocarcinoma (PDAC) cells. However, the metabolic roles of other oncogenic genes, such as YY1, in PDAC development are st...
