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Article
The E2F family: a ray of dawn in cardiomyopathy
Cardiomyopathies are a group of heterogeneous diseases, characterized by abnormal structure and function of the myocardium. For many years, it has been a hot topic because of its high morbidity and mortality a...
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Article
A comparison of ultrasound volume navigation, O-arm navigation, and X-ray guidance for screw placement in minimally invasive transforaminal lumbar interbody fusion: a randomized controlled trial
To compare the differences between Ultrasound Volume Navigation (UVN), O-arm Navigation, and conventional X-ray fluoroscopy-guided screw placement in Minimally Invasive Transforaminal Lumbar Interbody Fusion (...
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Article
Comparative proteomic exploration of plasma proteins in different levels of vitamin D with type 2 diabetes mellitus using iTRAQ-coupled LC-MS/MS
Due to the variety of modern diet and lifestyle changes, China has become the world’s largest number of people with T2DM. How to prevent and cure T2DM has become one of the urgent public health events in China...
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Article
Transcatheter Arterial Embolization with Bleomycin-Lipiodol of Hepatic Hemangiomas: Safety, Efficacy and Predictors of Response
To evaluate the safety, efficacy and predictors of response of transcatheter arterial embolization (TAE) to treat hepatic hemangiomas (HHs).
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Article
Open AccessBlocking the TRAIL-DR5 Pathway Reduces Cardiac Ischemia–Reperfusion Injury by Decreasing Neutrophil Infiltration and Neutrophil Extracellular Traps Formation
Acute myocardial infarction (AMI) is a leading cause of mortality. Neutrophils penetrate injured heart tissue during AMI or ischemia–reperfusion (I/R) injury and produce inflammatory factors, chemokines, and e...
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Article
Open AccessTumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to immune cell (glioma-associated microglia and macrophages) infiltration promoting tumou...
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Article
PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway
Sunitinib has emerged as the primary treatment for advanced or metastatic clear cell renal cell carcinoma (ccRCC) due to its significant improvement in patients’ average survival time. However, drug resistance...
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Article
Gestational diabetes mellitus affects the differentiation of hematopoietic stem cells in neonatal umbilical cord blood
There are abundant hematopoietic stem cells (HSCs) in cord blood. It is known that HSCs continue to differentiate to CLP, CMP and erythroid progenitor cells (EPC), EPC ultimately differentiated to platelets an...
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Article
Open AccessMIIP downregulates PD-L1 expression through HDAC6 in cutaneous melanoma
Immune checkpoint inhibitors have improved the objective response rate and survival of melanoma patients. However, there are still many melanoma patients suffering from disease progression due to primary or se...
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Article
Open AccessCorrection: Assessing immunogenicity of CRISPR‑NCas9 engineered strain against porcine epidemic diarrhea virus
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Article
Anti-neurofascin-155 antibody mediated a distinct phenotype of chronic inflammatory demyelinating polyradiculoneuropathy
To investigate Ranvier’s autoantibodies prevalence and isotypes in various peripheral neuropathy variants, compare clinical features between seronegative and seropositive patients, and elucidate immune mechani...
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Article
Open AccessInflammatory myofibroblastic tumor of the liver after adrenal neuroblastoma surgery: a case report
A boy aged 55 months was diagnosed with stage IV Neuroblastoma (NB) of the right adrenal gland 2 years ago. Preoperative chemotherapy was given and he was then treated with retroperitoneal tumor resection and ...
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Article
Open AccessMolecular weight control of poly-γ-glutamic acid reveals novel insights into extracellular polymeric substance synthesis in Bacillus licheniformis
The structural diversity of extracellular polymeric substances produced by microorganisms is attracting particular attention. Poly-gamma-glutamic acid (γ-PGA) is a widely studied extracellular polymeric substa...
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Article
Low temperature and dark culture inhibited explant browning and promoted in vitro regeneration of Juglans mandshurica
Juglans mandshurica is an important component of Korean pine mixed and secondary forests in Northeast China and is also a precious timber and economic species. In this study, plant regeneration of J. mandshurica
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Article
Seasonal changes in gut microbiota of sea cucumber over natural aestivation cycle
Sea cucumber Apostichopus japonicus is an ideal model organism for marine invertebrate aestivation; it annually enters a “slee** state” for nearly 3 months when ambient water temperature range is 25–30 °C. The ...
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Article
Preparation and evaluation of Thesium chinense extract loaded polyvinyl alcohol/sodium alginate hydrogel for wound healing
A novel composite hydrogel was prepared by combining polyvinyl alcohol (PVA) and sodium alginate (SA) in a specific proportion to serve as a drug carrier, and then loading the extract of Thesium chinense (TCE) on...
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Article
Open AccessHepatitis B virus reactivation in hepatocellular carcinoma patients after hepatic arterial infusion chemotherapy combined with and without immunotherapy
Hepatitis B virus (HBV) reactivation (HBVr) is a major concern for hepatocellular carcinoma (HCC) patients undergoing hepatic arterial infusion chemotherapy (HAIC) using mFOLFOX6 regimen. There is insufficient...
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Article
Progressive Collapse Resistance Analysis of Plate-member Composite Reticulated Shell Structure
In order to study the progressive collapse resistance of plate-member composite reticulated shell structure and propose an applicable analysis method, the complete and member removal experimental models of com...
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Article
Open AccessSuccessful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case report
In this report, we report a case of a middle-aged male, admitted to the ICU with cerebral hemorrhage resulting from a severe high-altitude fall. The patient encountered significant challenges in oxygenation in...
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Article
Open AccessMicrobiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding
The host–microbiota interaction plays a crucial role in maintaining homeostasis and disease susceptibility, and microbial tryptophan metabolites are potent modulators of host physiology. However, whether and h...
