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    Prediction of ROS1 and TRKA/B/C occupancy in plasma and cerebrospinal fluid for entrectinib alone and in DDIs using physiologically based pharmacokinetic (PBPK) modeling approach

    Entrectinib (ENT) is a potent c-ros oncogene 1(ROS1) and neurotrophic tyrosine receptor kinase (NTRKA/B/C) inhibitor. To determine the optimum dosage of ENT using ROS1 and NTRKA/B/C occupancy in plasma and cer...

    Liangang Chen, Na Yao, Hongjie Yang, Shaofeng Zhang in Cancer Chemotherapy and Pharmacology (2024)

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    Critical Area Identification of Potential Soil Loss in a Typical Watershed of the Three Gorges Reservoir Region

    Identifying critical soil loss-prone areas is necessary to better control soil loss in the **angxi watershed, the river basin nearest the Three Gorges Dam. A crucial element of this scheme is the development o...

    Liangang Chen, **n Qian, Yong Shi in Water Resources Management (2011)