29 Result(s)
within
Lian** Xue
Life Sciences
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Article
Open AccessUCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells
The high degree of intratumoral genomic heterogeneity is a major obstacle for glioblastoma (GBM) tumors, one of the most lethal human malignancies, and is thought to influence conventional therapeutic outcome...
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Article
Open AccessTherapeutic applications of gut microbes in cardiometabolic diseases: current state and perspectives
Cardiometabolic disease (CMD) encompasses a range of diseases such as hypertension, atherosclerosis, heart failure, obesity, and type 2 diabetes. Recent findings about CMD’s interaction with gut microbiota hav...
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Article
Effects of probiotics on hypertension
Emerging data have suggested that probiotics had good potential in regulating intestinal flora and preventing hypertension. Some studies in human and animal models have demonstrated probiotic intervention coul...
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Article
Open AccessSTAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
Compelling evidences have revealed the emerging role of ferroptosis in the pathophysiological process of acute lung injury (ALI), but its modulation is not clear. Here, we identified that STAT6 acted as a crit...
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Article
Photobacterium damselae subsp. damselae in mariculture
Photobacterium damselae subsp. damselae affects many marine animals; it is currently considered an emerging pathogen because of its wide geographic distribution as well as its negative impact on aquaculture organ...
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Article
Open AccessMechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor
Conotoxins are marine peptide toxins from marine cone snails. The α-conotoxin RegIIA can selectively act on human (h) α3β4 nicotinic acetylcholine receptor (nAChR), and is an important lead for drug developmen...
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Article
Open AccessSTAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidation
Lipid metabolism, especially fatty acid oxidation (FAO) dysfunction, is a major driver of renal fibrosis; however, the detailed regulatory mechanisms involved remain unclear. In this study, we showed that ther...
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Article
Melatonin Enhances the Waterlogging Tolerance of Prunus persica by Modulating Antioxidant Metabolism and Anaerobic Respiration
Prunus persica is considered one of the most hypoxia-intolerant stone fruits. However, waterlogging, which causes hypoxia, occurs frequently in southern China where peaches are commercially important. As useful w...
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Article
Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells
Cryo-electron microscopy (cryo-EM) enables macromolecular structure determination in vitro and inside cells. In addition to aligning individual particles, accurate registration of sample motion and three-dimen...
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Article
Open AccessBroad-range and effective detection of human noroviruses by colloidal gold immunochromatographic assay based on the shell domain of the major capsid protein
Human noroviruses (HuNoVs) are a major cause of nonbacterial gastroenteritis in all age groups worldwide. HuNoVs can be detected in vitro using molecular assays such as RT-PCR and RT-qPCR. However, these molec...
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Article
Gill transcriptomes reveal expression changes of genes related with immune and ion transport under salinity stress in silvery pomfret (Pampus argenteus)
Salinity is a major ecological factor in the marine environment, and extremely important for the survival, development, and growth of fish. In this study, gill transcriptomes were examined by high-throughput s...
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Article
Open AccessAuthor Correction: Liriodendron genome sheds light on angiosperm phylogeny and species–pair differentiation
In the Supplementary Information file originally published with this Letter, the authors mistakenly omitted Supplementary Table 14; this has now been amended.
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Article
Open AccessLiriodendron genome sheds light on angiosperm phylogeny and species–pair differentiation
The genus Liriodendron belongs to the family Magnoliaceae, which resides within the magnoliids, an early diverging lineage of the Mesangiospermae. However, the phylogenetic relationship of magnoliids with eudicot...
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Article
Effects of fasting on the activities and mRNA expression levels of lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and fatty acid synthetase (FAS) in spotted seabass Lateolabrax maculatus
To investigate the effects of fasting on lipid metabolism in spotted seabass muscle and liver tissues, we analyzed mRNA levels and enzyme activities of lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) ...
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Article
Native and non-native halophytes resiliency against sea-level rise and saltwater intrusion
We quantified the independent impacts of flooding salinity, flooding depth, and flooding frequency on the native species, Phragmites australis and Scirpus mariqueter, and on the invasive species Spartina alternif...
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Article
Open AccessTranscriptomic analysis of Pak Choi under acute ozone exposure revealed regulatory mechanism against ozone stress
Ground-level ozone (O3) is one of the major air pollutants, which cause oxidative injury to plants. The physiological and biochemical mechanisms underlying the responses of plants to O3 stress have been well inve...
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Protocol
Identification of Plant Kinase Substrates Based on Kinase Assay-Linked Phosphoproteomics
Protein phosphorylation is one of the key events in the regulation of plant physiological responses to diverse environmental stimuli. As crucial regulators of phosphorylation, protein kinases have been linked ...
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Article
A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy
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Protocol
Identification of Direct Kinase Substrates via Kinase Assay-Linked Phosphoproteomics
Protein phosphorylation plays an essential role in the regulation of various cellular functions. Dysregulation of phosphorylation is implicated in the pathogenesis of certain cancers, diabetes, cardiovascular ...
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Article
Transgenic expression of human cytoxic T-lymphocyte associated antigen4-Immunoglobulin (hCTLA4Ig) by porcine skin for xenogeneic skin grafting
Porcine skin is frequently used as a substitute of human skin to cover large wounds in clinic practice of wound care. In our previous work, we found that transgenic expression of human cytoxicT-lymphocyte asso...
