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Article
NiCo2O4 nanoparticles: an efficient and magnetic catalyst for Knoevenagel condensation
The Knoevenagel condensation reaction has wide applications ranging from the manufacture of basic chemicals to pharmaceutical intermediates. In this study, we developed an efficient and magnetic bimetallic NiCo2O
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Article
Asymmetric synthesis of N-protected 3-methylpiperidin-2-one and its diastereoisomer
This paper reports the asymmetric synthesis of an important pharmaceutical intermediate (3S)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-methylpiperidin-2-one (compound 1) from commercially available D-plenylglycinol and ...
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Article
Accelerated effect on Mitsunobu reaction via bis-N-tert-butoxycarbonylation protection of 2-amino-6-chloropurine and its application in a novel synthesis of penciclovir
Solubility of 2-amino-6-chloropurine in Mitsunobu solvents could be significantly improved after its exocyclic amino group is protected via N-tert-butoxycarbonylation. The bis-Boc protected 2-amino-6-chloropur...