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Article
Open AccessSilencing LINC00987 ameliorates adriamycin resistance of acute myeloid leukemia via miR-4458/HMGA2 axis
Most patients with acute myeloid leukemia (AML) eventually develop drug resistance, leading to a poor prognosis. Dysregulated long gene non coding RNAs (lincRNAs) have been implicated in chemoresistance in AML...
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Article
Visible-light-driven synthesis of N-heteroaromatic carboxylic acids by thiolate-catalysed carboxylation of C(sp²)–H bonds using CO2
Catalytic carboxylation of C–H bonds using CO2 is a sustainable and economic strategy to produce valuable carboxylic acids. However, this process presents challenges due to the low reactivity of C–H bonds and dif...
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Article
Open AccessArylcarboxylation of unactivated alkenes with CO2 via visible-light photoredox catalysis
Photocatalytic carboxylation of alkenes with CO2 is a promising and sustainable strategy to synthesize high value-added carboxylic acids. However, it is challenging and rarely investigated for unactivated alkenes...
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Article
Visible-light-driven thio-carboxylation of alkynes with CO2: facile synthesis of thiochromones
Difunctionalizing carboxylation of alkynes with CO2 is a sustainable and important strategy to generate valuable acrylate derivatives from both readily available starting materials. Such protocols, however, alway...
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Article
Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations
Pyridines and related N-heteroarenes are commonly found in pharmaceuticals, agrochemicals and other biologically active compounds1,2. Site-selective C–H functionalization would provide a direct way of making thes...
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Article
Visible-light photocatalytic di- and hydro-carboxylation of unactivated alkenes with CO2
High value utilization of carbon dioxide (CO2) has attracted worldwide attention for decades. Catalytic carboxylation of alkenes with CO2 to synthesize valuable carboxylic acids and diacids is highly important. A...
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Article
Open AccessNickel-catalyzed electrochemical carboxylation of unactivated aryl and alkyl halides with CO2
Electrochemical catalytic reductive cross couplings are powerful and sustainable methods to construct C−C bonds by using electron as the clean reductant. However, activated substrates are used in most cases. H...
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Article
Visible-light-driven external-photocatalyst-free alkylative carboxylation of alkenes with CO2
Herein, we report a novel protocol for visible-light-driven alkylative carboxylation of alkenes with CO2 in the absence of external photocatalyst. Under the irradiation of visible light, a variety of 4-alkyl-1,4-...
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Article
Open AccessVisible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2
Photoredox-mediated umpolung strategy provides an alternative pattern for functionalization of carbonyl compounds. However, general approaches towards carboxylation of carbonyl compounds with CO2 remain scarce. H...
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Article
Dicarboxylation of alkenes, allenes and (hetero)arenes with CO2 via visible-light photoredox catalysis
Light-driven utilization of CO2 in organic synthesis is highly attractive because it mimics nature. However, such transformations are mainly limited to the incorporation of only a single CO2 molecule into organic...
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Article
Open AccessReductive dearomative arylcarboxylation of indoles with CO2 via visible-light photoredox catalysis
Catalytic reductive coupling of two electrophiles and one unsaturated bond represents an economic and efficient way to construct complex skeletons, which is dominated by transition-metal catalysis via two elec...
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Article
Visible-light-mediated external-reductant-free reductive cross coupling of benzylammonium salts with (hetero)aryl nitriles
Herein we report a novel visible-light-mediated external reductant-free reductive cross coupling for the construction of C sp2–C sp3 bonds. A variety of benzylammonium salts underwent selective coupling with (het...
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Article
Open AccessTransition metal-free phosphonocarboxylation of alkenes with carbon dioxide via visible-light photoredox catalysis
Catalytic difunctionalization of alkenes has been an ideal strategy to generate structurally complex molecules with diverse substitution patterns. Although both phosphonyl and carboxyl groups are valuable func...
