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Protocol
Transwell In Vitro Cell Migration and Invasion Assays
Cell migration and invasion have essential roles in both normal physiology and disease. As such, methodologies to assess cell migratory and invasive capacities are necessary to elucidate normal cell processes ...
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Article
Open AccessIsolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
Compared to conventional chemotherapy, Immune checkpoint inhibitors (ICI) are known to have a distinct toxicity profile commonly identified as immune-related adverse events (irAEs). These irAEs that are believ...
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Article
Open AccessContextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progre...
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Chapter
Function and Signaling of the pH-Sensing G Protein-Coupled Receptors in Physiology and Diseases
Maintenance of pH homeostasis is essential for normal physiology and regulated by a complex network of pH sensors and acid–base transporters. Here, we discuss a family of pH-sensing G protein-coupled receptors...
