-
Article
Subjective cognitive decline and total energy intake: Talk too much?
The increasing longevity of the population has resulted in dementia becoming a leading cause of both death and disability. Dementia is not a single disease. Studies of rare Mendelian disorders have documented ...
-
Article
Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women’s Health Initiative Observational Study
Menopausal hormone therapy (MHT) use induces alterations in circulating estrogens/estrogen metabolites, which may contribute to the altered risk of reproductive tract cancers among current users. Thus, the cur...
-
Article
Metabolic syndrome and risk of endometrial cancer in postmenopausal women: a prospective study
Obesity is a strong risk factor for endometrial cancer, but it is unclear whether metabolic syndrome (MetS) contributes to endometrial cancer risk over and above the contribution of obesity.
-
Article
A new era for dementia epidemiology: Alzheimer’s disease, hardening of arteries, or just old age?
-
Article
Correction to: Transethnic insight into the genetics of glycaemic traits: fine-map** results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium
The authors regret that Yinchang Lu’s name incorrectly included a middle initial in the author list. The details given in this erratum are correct.
-
Article
Open AccessTransethnic insight into the genetics of glycaemic traits: fine-map** results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium
Elevated levels of fasting glucose and fasting insulin in non-diabetic individuals are markers of dysregulation of glucose metabolism and are strong risk factors for type 2 diabetes. Genome-wide association st...
-
Article
Open AccessTrends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium
Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports ar...
-
Article
Trans-ethnic fine-map** of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci
Most body mass index (BMI) genetic loci have been identified in studies of primarily European ancestries. The effect of these loci in other racial/ethnic groups is less clear. Thus, we aimed to characterize th...
-
Article
The limitations of opportunistic epidemiology, pseudopod epidemiology
Epidemiology has been remarkably successful in the past in identifying the important agents of disease, the impact of the environment, both physical and social, and interrelationship with host susceptibility (...
-
Article
Open AccessA call for comparative effectiveness research to learn whether routine clinical care decisions can protect from dementia and cognitive decline
Common diseases like diabetes, hypertension, and atrial fibrillation are probable risk factors for dementia, suggesting that their treatments may influence the risk and rate of cognitive and functional decline...
-
Article
Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study
At the same level of BMI, white people have less visceral adipose tissue (VAT) and are less susceptible to develo** type 2 diabetes than Japanese people. No previous population-based studies have compared in...
-
Article
Detection of ischaemic heart disease in symptomatic women
The 2014 revision of the 2005 AHA consensus statement on the evaluation of women with suspected ischaemic heart disease is a major update. The authors discuss the spectrum of ischaemic heart disease and review...
-
Article
Preventing Dementia in Older Cardiovascular Patients
Cardiovascular disease (CVD) contributes to risk of dementia by either enhancing the development and progression of brain vascular disease and subsequent neurodegeneration and Alzheimer's disease (AD) patholog...
-
Article
Open AccessSex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects
Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women’s Health Initiative (W...
-
Article
Open AccessRegional pulse wave velocities and their cardiovascular risk factors among healthy middle-aged men: a cross-sectional population-based study
Both carotid-femoral (cf) pulse wave velocity (PWV) and brachial-ankle (ba) PWV employ arterial sites that are not consistent with the path of blood flow. Few previous studies have reported the differential chara...
-
Article
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
Keri Monda, Kari North, Christopher Haiman and colleagues report a meta-analysis of GWAS for body mass index that is composed of 39,144 individuals of African ancestry, followed by further genoty** in 32,268...
-
Article
Open AccessEffects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored.
-
Article
Metformin Use Among Individuals at Risk for Type 2 Diabetes
Excess total and cardiovascular morbidity and mortality remain very high among those with type 2 diabetes versus those without diabetes. Clinical trials to lower blood glucose have been disappointing probably ...
-
Article
Cardiovascular Complications of Extreme Obesity in Women
Severe obesity (body mass index ≥35 kg/m2) is occurring at younger ages in US women and is relatively common among women of certain racial/ethnic backgrounds. It is associated with a high incidence of cardiovascu...
-
Article
Blood Pressure and Cognitive Outcome
Dementia, including Alzheimer’s disease, vascular dementia, and “mixed” dementia, increases with age, yet its causes, particularly of Alzheimer’s disease, are not well understood. Hypertension is an important ...
