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Article
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution
The World Health Organization framework for tracking SARS-CoV-2 variants has been updated to reflect the continued evolution of the virus; this framework could be adapted for other emerging respiratory disease...
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Article
An early warning system for emerging SARS-CoV-2 variants
Global sequencing and surveillance capacity for SARS-CoV-2 must be strengthened and combined with multidisciplinary studies of infectivity, virulence and immune escape, in order to track the unpredictable evol...
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Article
SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse
A group convened and led by the Virus Evolution Working Group of the World Health Organization reports on its deliberations and announces a naming scheme that will enable clear communication about SARS-CoV-2 v...
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Article
Open AccessTracking the COVID-19 pandemic in Australia using genomics
Genomic sequencing has significant potential to inform public health management for SARS-CoV-2. Here we report high-throughput genomics for SARS-CoV-2, sequencing 80% of cases in Victoria, Australia (populatio...
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Article
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
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Article
Open AccessEvolutionary analysis of human parechovirus type 3 and clinical outcomes of infection during the 2017–18 Australian epidemic
Human parechovirus type 3 (HPeV3) can cause severe sepsis-like illness in young infants and may be associated with long term neurodevelopmental delay later in childhood. We investigated the molecular epidemiol...
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Protocol
Host Factors Modulating RSV Infection: Use of Small Interfering RNAs to Probe Functional Importance
Although respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in infants and the elderly worldwide [1], the protein–protein interactions between the host cell and virus remain ...
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Article
Proteolytic Cleavage of HIV-1 GFP-Vpr Fusions at Novel Sites Within Virions and Living Cells: Concerns for Intracellular Trafficking Studies
Fluorescent labelling of the highly conserved HIV-1 accessory protein Vpr (Viral Protein R) with GFP or variants thereof has proved a valuable approach to track Vpr and/or HIV-1 subcellular localisation in vivo. ...
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Article
Open AccessImpaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor
We previously reported an epidemiologically linked HIV-1 infected patient cohort in which a long-term non-progressor (LTNP) infected two recipients who then exhibited normal disease progression. Expression of ...
