37,846 Result(s)
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Open AccessSingle-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease
Bullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet a comprehensive understanding of the immune landscape, particularly immune-stromal crosstalk in BP, remains elusive. Here...
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Open AccessLarge-scale 2D heterostructures from hydrogen-bonded organic frameworks and graphene with distinct Dirac and flat bands
The current strategies for building 2D organic-inorganic heterojunctions involve mostly wet-chemistry processes or exfoliation and transfer, leading to interface contaminations, poor crystallizing, or limited ...
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Open AccessGenomic and single-cell analyses reveal genetic signatures of swimming pattern and diapause strategy in jellyfish
Jellyfish exhibit innovative swimming patterns that contribute to exploring the origins of animal locomotion. However, the genetic and cellular basis of these patterns remains unclear. Herein, we generated chr...
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Open AccessThe SIRT2-AMPK axis regulates autophagy induced by acute liver failure
This study explores the role of SIRT2 in regulating autophagy and its interaction with AMPK in the context of acute liver failure (ALF). This study investigated the effects of SIRT2 and AMPK on autophagy in AL...
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Open AccessAdenine base editing-mediated exon skip** restores dystrophin in humanized Duchenne mouse model
Duchenne muscular dystrophy (DMD) affecting 1 in 3500–5000 live male newborns is the frequently fatal genetic disease resulted from various mutations in DMD gene encoding dystrophin protein. About 70% of DMD-caus...
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Open AccessExperimental system and method of aerobic thermal environment simulation based on laser heating
Considering the superior luminous intensity characteristics of lasers, a thermal simulation platform employing laser-induced heating in an aerobic environment was developed. Achieving a uniformly distributed f...
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Open AccessDiscovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility
Eunicellane diterpenoids, containing a typical 6,10-bicycle, are bioactive compounds widely present in marine corals, but rarely found in bacteria and plants. The intrinsic macrocycle exhibits innate structura...
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Open Access18F-FDG PET/CT metabolic parameters can semi-quantitatively evaluate the nature of the heart and pericardial masses: a retrospective study
The objective of this study was to evaluate semi-quantitatively the diagnostic performance of PET/CT metabolic parameters in differentiating benign or malignant cardiac or pericardial masses. A total of forty-...
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Open AccessRobust structural superlubricity under gigapascal pressures
Structural superlubricity (SSL) is a state of contact with no wear and ultralow friction. SSL has been characterized at contact with van der Waals (vdW) layered materials, while its stability under extreme loa...
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Open AccessRecommendations for managing adult acne and adolescent acne based on an epidemiological study conducted in China
There are numerous differences between adult acne and adolescent acne in terms of causes, distribution, and characteristics of skin lesions, as well as treatment. This paper aims to summarize the differences b...
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Open AccessLegionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms
The intracellular bacterial pathogen Legionella pneumophila modulates host cell functions by secreting multiple effectors with diverse biochemical activities. In particular, effectors of the SidE family interfere...
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Open AccessOverview of clinical status, treatment, and long-term outcomes of pediatric autosomal-dominant polycystic kidney disease: a nationwide survey in Taiwan
This retrospective study investigated the incidence, medication use, and outcomes in pediatric autosomal-dominant polycystic kidney disease (ADPKD) using Taiwan's National Health Insurance Research Database (N...
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Open AccessStructure characteristics and combustion kinetics of the co-pyrolytic char of rice straw and coal gangue
Co-combustion is a technology that enables the simultaneous and efficient utilization of biomass and coal gangue (CG). Nevertheless, the factors that affect the combustibility of co-pyrolytic char, which repre...
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Open AccessI/O-efficient iterative matrix inversion with photonic integrated circuits
Photonic integrated circuits have been extensively explored for optical processing with the aim of breaking the speed and energy efficiency bottlenecks of digital electronics. However, the input/output (IO) bo...
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Open AccessPrognostic value of cardiopulmonary exercise test in patients with acute myocardial infarction after percutaneous coronary intervention
To determine the independent risk factors of cardiopulmonary exercise test (CPET) parameters related to adverse prognostic events within 5 years in patients undergoing percutaneous coronary intervention (PCI) ...
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Open AccessThe impact of tertiary lymphoid structures on tumor prognosis and the immune microenvironment in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a common malignancy whose prognosis and treatment outcome are influenced by many factors. Some studies have found that tertiary lymphoid structures (TLSs) in cancer may co...
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Open AccessFibroblast growth factor 23 inhibition attenuates steroid-induced osteonecrosis of the femoral head through pyroptosis
Steroid-induced osteonecrosis of the femoral head (SONFH) is the predominant cause of non-traumatic osteonecrosis of the femoral head (ONFH). Impaired blood supply and reduced osteogenic activity of the femora...
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Open AccessRole of elective neck dissection in cT2N0 maxillary sinus squamous cell carcinoma
Our objective was to examine the impact of elective neck dissection (END) on the prognosis of patients with cT2N0 maxillary sinus squamous cell carcinoma (MS-SCC) and to determine factors that predict the occu...
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Open AccessHighly selective urea electrooxidation coupled with efficient hydrogen evolution
Electrochemical urea oxidation offers a sustainable avenue for H2 production and wastewater denitrification within the water-energy nexus; however, its wide application is limited by detrimental cyanate or nitrit...
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Open AccessEvaporate-casting of curvature gradient graphene superstructures for ultra-high strength structural materials
In contemporary manufacturing, the processing of structural materials plays a pivotal role in enabling the creation of robust, tailor-made, and precise components suitable for diverse industrial applications. ...
