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  1. No Access

    Article

    Development of Congenic Rat Strains for Alcohol Consumption Derived from the Alcohol-Preferring and Nonpreferring Rats

    A genome scan of the F2 generation from an inbred alcohol-preferring (iP) and inbred alcohol-nonpreferring (iNP) rat cross identified a significant quantitative trait locus (QTL) on chromosome 4 with a lod sco...

    Lucinda G. Carr, Kirk Habegger, John P. Spence, Lixiang Liu… in Behavior Genetics (2006)

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    Article

    Identification of QTLs Influencing Alcohol Preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) Mouse Lines

    The High- and Low-Alcohol Preferring (HAP1/LAP1 and HAP2/LAP2) mouse lines were developed by selective breeding for differences in alcohol preference. They represent the only extant selectively bred mouse line...

    Paula J. Bice, Tatiana Foroud, Lucinda G. Carr, Lili Zhang… in Behavior Genetics (2006)

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    Article

    Phenotypic and Genotypic Characterization of the Indiana University Rat Lines Selectively Bred for High and Low Alcohol Preference

    The Indiana lines of selected rats, the HAD and LAD replicates and the P and NP lines, were bred for high and low alcohol preference. The P and HAD lines have met criteria for an animal model of alcoholism in ...

    James M. Murphy, Robert B. Stewart, Richard L. Bell… in Behavior Genetics (2002)

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    Article

    Identification of Quantitative Trait Loci Influencing Alcohol Consumption in the High Alcohol Drinking and Low Alcohol Drinking Rat Lines

    Selective breeding has been employed to develop high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rat lines from the heterogeneous N/Nih rat. Within-family selection and a rotational breeding design w...

    Tatiana Foroud, Paula Bice, Peter Castelluccio, Ronghai Bo… in Behavior Genetics (2000)

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    Article

    Selective Breeding for High and Low Alcohol Preference in Mice

    High and low alcohol preference (HAP and LAP, respectively) mice were created by 10 generations of bidirectional selection for differences in two-bottle choice alcohol consumption. The progenitors used for sel...

    Nicholas J. Grahame, T.-K. Li, Lawrence Lumeng in Behavior Genetics (1999)

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    Article

    Selective breeding for alcohol preference and associated responses

    Selective breedng for high and low alcohol-drinking preference has produced rat lines useful for studying the nature of excessive alcohol-seeking behavior. Compared with the alcohol-nonpreferring line, the pre...

    Ting-Kai Li, Lawrence Lumeng, Donald P. Doolittle in Behavior Genetics (1993)