5 Result(s)
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Lauren Folgosa Cooley
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Article
Open AccessExpression-based subtypes define pathologic response to neoadjuvant immune-checkpoint inhibitors in muscle-invasive bladder cancer
Checkpoint immunotherapy (CPI) has increased survival for some patients with advanced-stage bladder cancer (BCa). However, most patients do not respond. Here, we characterized the tumor and immune microenviron...
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Chapter
The Value of Tumor Sample Analyses Before and After Checkpoint Inhibition: Contextualizing the Treatment-Induced Changes in Gene Expression
Although neoadjuvant cisplatin-based chemotherapy prior to radical cystectomy is the current standard of care for muscle-invasive bladder cancer (MIBC), immune checkpoint inhibitors have shown promising result...
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Chapter
Strategies for Bladder Cancer Screening
To date, screening for bladder cancer (BC) in asymptomatic adults, even if high-risk, is not recommended. Herein, we highlight the rationale to BC screening in high-risk populations for BC diagnosis, review pa...
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Article
Open AccessAnti-TNF agents and potential effects on male fertility: are men being counseled?
Adult men with autoimmune conditions are commonly prescribed anti-tumor necrosis factor (anti-TNF) agents; however, there is a paucity of quality evidence as to their effect on male fertility (e.g. semen param...
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Article
Open AccessImpaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice
Sperm associated antigen 6 (SPAG6), a component of the central apparatus of the “9 + 2” axoneme, plays a central role in ciliary and flagellar motility; but, its contribution to adaptive immunity and immune sy...
