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Correction: Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
Nature 484, 510–513 (2012); 10.1038/nature11012 In this Letter, we reported that NLRP10-deficient mice had no defect in inflammasome function in macrophages or dendritic cells (DCs). Instead, a loss of T-cell-...
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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
IL-22 is one of the factors that, although important for wound healing, also promote tumorigenesis; the regulation of IL-22BP, the IL-22 binding protein, via the NLRP3 and NLRP6 inflammasomes provides an unant...
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NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
Dendritic cells in mice lacking NLRP10 are defective in exiting inflamed tissue, leading to impaired adaptive immunity; this could have a profound impact on the approach to treating allergic and autoimmune dis...
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The dual nature of TH17 cells: shifting the focus to function
Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) have been broadly linked to the pathogenesis of multiple autoimmune diseases. In the few short years since the discovery of TH17 cells, new paradigms a...
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Immune Evasion and Modulation by Listeria monocytogenes
Listeria monocytogenes has long served as a model pathogen for elucidating many functions of the immune response. Both the innate and adaptive immune systems are crucial to the recognition and ...
