20 Result(s)
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Laurel Rauschenbach
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Article
Open AccessImpact of thyroid hormone replacement therapy on the course and functional outcome of aneurysmal subarachnoid hemorrhage
Thyroid hormones were reported to exert neuroprotective effects after ischemic stroke by reducing the burden of brain injury and promoting post-ischemic brain remodeling.
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Article
Open AccessPredictors and surgical outcome of hemorrhagic metastatic brain malignancies
Intracerebral metastases present a substantial risk of tumor-associated intracerebral hemorrhage (ICH). This study aimed to investigate the risk of hemorrhagic events in brain metastases (BM) from various prim...
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Article
Open AccessRisk factors for poor outcome after aneurysmal subarachnoid hemorrhage in patients with initial favorable neurological status
Aneurysmal subarachnoid hemorrhage (aSAH) remains a devastating diagnosis. A poor outcome is known to be highly dependent on the initial neurological status. Our goal was to identify other parameters that favo...
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Article
Open AccessNatural course of cerebral and spinal cavernous malformations: a complete ten-year follow-up study
Knowledge of the bleeding risk and the long-term outcome of conservatively treated patients with cavernous malformations (CM) is poor. In this work, we studied the occurrence of CM-associated hemorrhage over a...
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Article
Open AccessThe value of ventricular measurements in the prediction of shunt dependency after aneurysmal subarachnoid hemorrhage
Chronic hydrocephalus requiring shunt placement is a common complication of aneurysmal subarachnoid hemorrhage (SAH). Different risk factors and prediction scores for post-SAH shunt dependency have been evalua...
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Article
Open AccessFunctional neurological outcome of spinal cavernous malformation surgery
Spinal cavernous malformations (SCM) present a risk for intramedullary hemorrhage (IMH), which can cause severe neurologic deficits. Patient selection and time of surgery have not been clearly defined.
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Article
Open AccessFunctional outcome after pediatric cerebral cavernous malformation surgery
The purpose of this study was to investigate the functional outcome following surgical resection of cerebral cavernous malformations (CCM) in pediatric patients. We screened our institutional database of CCM p...
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Article
Open AccessCerebral Taenia crassiceps larvae infection in a 71-year-old immunocompetent male
We report a rare case of a cerebral infection with Taenia crassiceps tapeworm larvae in an immunocompetent 71-year-old German male. Initially, an intracerebral malignoma was suspected after the patient experience...
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Article
Open AccessSystematic review and meta-analysis of outcome-relevant anemia in patients with subarachnoid hemorrhage
Anemia is a common, treatable condition in patients with aneurysmal subarachnoid hemorrhage (SAH) and has been associated with poor outcome. As there are still no guidelines for anemia management after aneurys...
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Article
Open AccessBlood pressure and outcome after aneurysmal subarachnoid hemorrhage
Blood pressure management is crucial in the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH). Possible association between the blood pressure increase and the risk of delayed cerebral ische...
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Article
Open AccessRadiographic markers of breast cancer brain metastases: relation to clinical characteristics and postoperative outcome
Occurrence of brain metastases BM is associated with poor prognosis in patients with breast cancer (BC). Magnetic resonance imaging (MRI) is the standard of care in the diagnosis of BM and determines further t...
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Article
Open AccessPaCO2-management in the neuro-critical care of patients with subarachnoid hemorrhage
The partial pressure of carbon dioxide (PaCO2) in the arterial blood is a strong vasomodulator affecting cerebral blood flow and the risk of cerebral edema and ischemia after acute brain injury. In turn, both ...
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Article
Open AccessTumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression
Brain tumors are typically immunosuppressive and refractory to immunotherapies for reasons that remain poorly understood. The unbiased profiling of immune cell types in the tumor microenvironment may reveal im...
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Article
Machine learning-based differentiation between multiple sclerosis and glioma WHO II°-IV° using O-(2-[18F] fluoroethyl)-L-tyrosine positron emission tomography
This study aimed to test the diagnostic significance of FET-PET imaging combined with machine learning for the differentiation between multiple sclerosis (MS) and glioma II°-IV°.
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Article
Open AccessSeizures at the onset of aneurysmal SAH: epiphenomenon or valuable predictor?
Seizures at the onset (SAO) of aneurysmal subarachnoid hemorrhage (aSAH) occur in up to one of every five cases. To date, there is no consensus on causal background and clinical value of these early bleeding-r...
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Chapter and Conference Paper
Personalized Calvarial Reconstruction in Neurosurgery
Neurosurgical procedures often involve local skull bone removal to combat specific pathologies. Defect covering is mandatory in most cases and usually requires the application of bespoke and synthetically engi...
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Chapter
Spinal Cord Tumor Microenvironment
Intramedullary spinal cord tumors (IMSCT) are rare entities for which there currently exist no standardized treatment paradigms. Consequently, patients usually receive treatment modalities that were establishe...
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Article
Blood-Based Biomarkers in High Grade Gliomas: a Systematic Review
High-grade gliomas (HGG) are the most common malignant primary brain tumor in adults. During the course of disease, several challenges occur, like measuring tumor burden, monitoring of treatment response, esti...
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Article
Regorafenib in patients with recurrent high-grade astrocytoma
Antiangiogenic treatment approaches have failed to improve outcome in randomized trials of high-grade astrocytoma. One key mechanism of resistance to antiangiogenic treatment may concern the upregulation of al...
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Article
Open AccessLongitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors
Molecularly targeted therapies using receptor inhibitors, small molecules or monoclonal antibodies are routinely applied in oncology. Verification of target expression should be mandatory prior to initiation o...
