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    Article

    Inhibiting fatty acid synthesis overcomes colistin resistance

    Treating multidrug-resistant infections has increasingly relied on last-resort antibiotics, including polymyxins, for example colistin. As polymyxins are given routinely, the prevalence of their resistance is ...

    Lindsey A. Carfrae, Kenneth Rachwalski, Shawn French in Nature Microbiology (2023)

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    Open Access

    Interplay between eutrophication and climate warming on bacterial communities in coastal sediments differs depending on water depth and oxygen history

    Coastal aquatic systems suffer from nutrient enrichment, which results in accelerated eutrophication effects due to increased microbial metabolic rates. Climate change related prolonged warming will likely acc...

    Laura Seidel, Elias Broman, Stephanie Turner, Magnus Ståhle in Scientific Reports (2021)

  3. Article

    Open Access

    The molecular basis of regulation of bacterial capsule assembly by Wzc

    Bacterial extracellular polysaccharides (EPSs) play critical roles in virulence. Many bacteria assemble EPSs via a multi-protein “Wzx-Wzy” system, involving glycan polymerization at the outer face of the cytop...

    Yun Yang, Jiwei Liu, Bradley R. Clarke, Laura Seidel in Nature Communications (2021)

  4. Article

    Open Access

    Feasibility of optical coherence tomography angiography to assess changes in retinal microcirculation in ovine haemorrhagic shock

    This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of ...

    Maged Alnawaiseh, Christian Ertmer, Laura Seidel, Philip Helge Arnemann in Critical Care (2018)