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Open AccessElevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation
The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is often ass...
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Open AccessAn investigation of cancer survival inequalities associated with individual-level socio-economic status, area-level deprivation, and contextual effects, in a cancer patient cohort in England and Wales
People living in more deprived areas of high-income countries have lower cancer survival than those in less deprived areas. However, associations between individual-level socio-economic circumstances and cance...
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Open AccessAre socio-economic inequalities in breast cancer survival explained by peri-diagnostic factors?
Patients living in more deprived localities have lower cancer survival in England, but the role of individual health status at diagnosis and the utilisation of primary health care in explaining these different...
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Open AccessLife tables for global surveillance of cancer survival (the CONCORD programme): data sources and methods
We set out to estimate net survival trends for 10 common cancers in 279 cancer registry populations in 67 countries around the world, as part of the CONCORD-2 study. Net survival can be interpreted as the prop...
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Open AccessMultivariable flexible modelling for estimating complete, smoothed life tables for sub-national populations
The methods currently available to estimate age- and sex-specific mortality rates for sub-populations are subject to a number of important limitations. We propose two alternative multivariable approaches: a re...
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Article
Survival from twenty adult cancers in the UK and Republic of Ireland in the late twentieth century
Background
