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  1. No Access

    Article

    Targeting c-Met in triple negative breast cancer: preclinical studies using the c-Met inhibitor, Cpd A

    Introduction Triple negative breast cancer (TNBC) represents a heterogeneous subtype of breast cancer that carries a poorer prognosis. There remains a need to identify novel drivers of TNBC, which may represent t...

    Laura Breen, Patricia B. Gaule, Alexandra Canonici… in Investigational New Drugs (2020)

  2. Article

    Bed rest and resistive vibration exercise unveil novel links between skeletal muscle mitochondrial function and insulin resistance

    Physical inactivity has broad implications for human disease including insulin resistance, sarcopenia and obesity. The present study tested the hypothesis that (1) impaired mitochondrial respiration is linked ...

    Helena C. Kenny, Floriane Rudwill, Laura Breen, Michele Salanova… in Diabetologia (2017)

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  3. Article

    Open Access

    Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate

    To study the role of microRNA (miRNA) in the regulation of Chinese hamster ovary (CHO) cell growth, qPCR, microarray and quantitative LC-MS/MS analysis were utilised for simultaneous expression profiling of mi...

    Colin Clarke, Michael Henry, Padraig Doolan, Shane Kelly, Sinead Aherne… in BMC Genomics (2012)

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  4. No Access

    Article

    Modulation of P-gp expression by lapatinib

    Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps, such as P-glycoprotein (P-gp). Lapatinib, a growth factor re...

    Gráinne Dunne, Laura Breen, Denis M. Collins, Sandra Roche… in Investigational New Drugs (2011)

  5. No Access

    Protocol

    Generation of Lung Cancer Cell Line Variants by Drug Selection or Cloning

    Clonal variants or subpopulations have been isolated from every major histological type of cancer, and cellular heterogeneity in lung cancer is a common occurrence. These subpopulations may exhibit differences...

    Laura Breen, Joanne Keenan, Martin Clynes in Cancer Cell Culture (2011)

  6. No Access

    Article

    Identification of Quantitative Trait Loci for Anxiety and Locomotion Phenotypes in Rat Recombinant Inbred Strains

    Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have fa...

    Lisa H. Conti, Martin Jirout, Laura Breen, Jessica J. Vanella… in Behavior Genetics (2004)

  7. No Access

    Article

    A new framework marker-based linkage map and SDPs for the Rat HXB/BXH strain set

    A new contiguous genetic linkage map of the HXB/BXH set of rat recombinant inbred (RI) strains was constructed to enhance QTL map** power and precision, and thereby make the RI strain set a better genomics r...

    Martin Jirout, Drahomíra Křenová, Vladimír Křen, Laura Breen… in Mammalian Genome (2003)