-
Article
Open AccessNovel Genetic Variants Associated with Primary Myocardial Fibrosis in Sudden Cardiac Death Victims
Myocardial fibrosis is a common finding in victims of sudden cardiac death (SCD). Whole exome sequencing was performed in 127 victims of SCD with primary myocardial fibrosis as the only pathological finding. T...
-
Article
Open AccessSudden cardiac death after alcohol intake: classification and autopsy findings
Alcohol is known to have an immediate effect on cardiac rhythm, and previous studies have found that a notable proportion of sudden cardiac deaths (SCD) occur after alcohol intake. The objective of the present...
-
Article
Open AccessGenetic contributions to the expression of acquired causes of cardiac hypertrophy in non-ischemic sudden cardiac death victims
The contribution of genetic variants to non-ischemic sudden cardiac death (SCD) due to acquired myocardial diseases is unclear. We studied whether SCD victims with hypertension/obesity related hypertrophic myo...
-
Article
Open AccessPresumed adverse events in health care are a frequent indication for medico-legal autopsy in Finland
The medico-legal autopsy is an essential tool in investigating deaths caused by an adverse event in health care, for both clinical risk management and for professional liability issues. However, there are no s...
-
Article
Open AccessRNU6B, a frequent reference in miRNA expression studies, differentiates between deaths caused by hypothermia and chronic cardiac ischemia
Here, we tested the usefulness of small non-coding RNAs as references in quantitative RT-PCR expression analyses in hypothermia and chronic cardiac ischemia as the primary causes of death. Cq values of RNU6B, ...
-
Article
Victims of lethal hypothermia have decreased levels of thrombomodulin in myocardium and urine
Severe cold stress has been shown to cause changes in the expression and secretion of thrombomodulin (TM), an endothelial protein regulating haemostasis and inflammation. To further evaluate TM as a cold stres...
