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  1. No Access

    Article

    Epidermal Growth Factor Receptor Mutation Status and Treatment Outcome for R0-Resected Patients with Stage 3 Non-small Cell Lung Cancer

    This study aimed to investigate the association of epidermal growth factor receptor (EGFR) mutation status with treatment outcome for patients with stage 3 non-small cell lung cancer (NSCLC) who had undergone ...

    Song Ran Liu MD, Bo Qiu MD, PhD, Hong Yang MD, PhD… in Annals of Surgical Oncology (2016)

  2. No Access

    Chapter

    Regulation of Mitochondrial Function by MicroRNA

    Mitochondria are organelles that are instrumental for the life as well as the death of cell. They have their own genome, present in multiple copies. The mitochondrial genome codes for 13 subunits of mitochondr...

    Marco Tomasetti, Lan-Feng Dong, Jiri Neuzil in Mitochondria: The Anti- cancer Target for … (2014)

  3. No Access

    Chapter

    Vitamin E Analogues as Prototypic Mitochondria-Targeting Anti-cancer Agents

    Mitochondria have emerged recently as a novel, intriguing target for anti-caner drugs, owing largely to their importance for proper growth of cancer cells. Destabilization of mitochondria often results in the ...

    Lan-Feng Dong… in Mitochondria: The Anti- cancer Target for the Third Millennium (2014)

  4. Article

    Erratum to: α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

    Lubomir Prochazka, Lan-Feng Dong, Karel Valis, Ruth Freeman, Stephen J. Ralph… in Apoptosis (2013)

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  5. No Access

    Article

    Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to α-tocopheryl succinate

    α-Tocopheryl succinate (α-TOS) is a promising anti-cancer agent due to its selectivity for cancer cells. It is important to understand whether long-term exposure of tumour cells to the agent will render them r...

    Lubomir Prochazka, Stepan Koudelka, Lan-Feng Dong, Jan Stursa, Jacob Goodwin… in Apoptosis (2013)

  6. Article

    Open Access

    Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress

    Cancer cells produce galectin-1 as a tumor promoting protein. Thiodigalactoside (TDG) as a non-metabolised small drug, is shown to suppress tumor growth by inhibiting multiple cancer enhancing activities of ga...

    Koichi Ito, Stacy A. Scott, Samuel Cutler, Lan-Feng Dong, Jiri Neuzil… in Angiogenesis (2011)

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  7. No Access

    Article

    α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

    Mitocans are drugs selectively killing cancer cells by destabilizing mitochondria and many induce apoptosis via generation of reactive oxygen species (ROS). However, the molecular events by which ROS productio...

    Lubomir Prochazka, Lan-Feng Dong, Karel Valis, Ruth Freeman, Stephen J. Ralph… in Apoptosis (2010)

  8. No Access

    Article

    Iliac hyperdense line: a new radiographic sign of gluteal muscle contracture

    Background: A hyperdense line on the ilium that runs roughly parallel to the sacroiliac joint (we called it “iliac hyperdense line sign”) was frequently observed on pelvic radiographs of patients with gluteal mus...

    **-Hua Cai, Lan-Feng Gan, He-Lin Zheng, Hao Li in Pediatric Radiology (2005)

  9. No Access

    Article

    B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion

    Accumulating data are showing that the humoral immune response against tumors could favor tumor progression. However, no B lymphocyte pathology has been reported in cancer. Using anti-IgM Ab we nonspecificall...

    Emilio Barbera-Guillem, M. Bud Nelson, Barbara Barr… in Cancer Immunology, Immunotherapy (2000)