8 Result(s)
within
Lalit Sehgal
English
Oncology
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Article
Open AccessExploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma
Mantle cell lymphoma (MCL) is a lethal hematological malignancy with a median survival of 4 years. Its lethality is mainly attributed to a limited understanding of clinical tumor progression and resistance to ...
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Article
Open AccessBeyond Bruton’s tyrosine kinase inhibitors in mantle cell lymphoma: bispecific antibodies, antibody–drug conjugates, CAR T-cells, and novel agents
Mantle cell lymphoma is a B cell non-Hodgkin lymphoma (NHL), representing 2–6% of all NHLs and characterized by overexpression of cyclin D1. The last decade has seen the development of many novel treatment app...
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Article
Open AccessA sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells
Mantle cell lymphoma (MCL) is a rare, highly heterogeneous type of B-cell non-Hodgkin’s lymphoma. The sumoylation pathway is known to be upregulated in many cancers including lymphoid malignancies. However, li...
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Article
Tight junction protein 1 promotes vasculature remodeling via regulating USP2/TWIST1 in bladder cancer
Bladder cancer (BLCA) is the most common malignant tumor of the urinary system and is characterized by high metastatic rates and poor prognosis. The expression of tight junction protein 1 (TJP1) is associated ...
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Article
Open AccessDnmt1 links BCR-ABLp210 to epigenetic tumor stem cell priming in myeloid leukemia
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Article
Open AccessTargeting Wnt pathway in mantle cell lymphoma-initiating cells
Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin’s lymphoma. Despite initial intense chemotherapy, up to 50 % of cases of MCL relapse often in a chemoresistant form. We hypothesize...
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Article
Open AccessCD74 interferes with the expression of fas receptor on the surface of lymphoma cells
Resistance to Fas-mediated apoptosis limits the efficacy of currently available chemotherapy regimens. We identified CD74, which is known to be overexpressed in hematological malignancies, as one of the factor...
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Article
Open AccessFascin overexpression promotes neoplastic progression in oral squamous cell carcinoma
Fascin is a globular actin cross-linking protein, which plays a major role in forming parallel actin bundles in cell protrusions and is found to be associated with tumor cell invasion and metastasis in various...
