-
Article
Open AccessHuman proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations
The bioartificial kidney (BAK) aims at improving dialysis by develo** ‘living membranes’ for cells-aided removal of uremic metabolites. Here, unique human conditionally immortalized proximal tubule epithelia...
-
Article
Open AccessLimited sampling strategy for prolonged-release tacrolimus in renal transplant patients by use of the dried blood spot technique
The aim of this study was to develop a clinically applicable limited sampling strategy for ambulatory Caucasian kidney transplant patients to estimate area under the curve in a 24-h period (AUC0–24) of prolonged-...
-
Chapter
10 Aandoeningen van nieren en urinewegen
Nierziekten komen niet vaak voor, maar ze gaan wel gepaard met grote morbiditeit en mortaliteit. Daardoor spelen ze in de medische en tandheelkundige praktijk toch een belangrijke rol. Zo kan bijvoorbeeld bij ...
-
Article
Nephrotic syndrome induced by pamidronate
Two patients developed nephrotic syndrome and progressive loss of renal function following treatment with i.v. pamidronate. Renal biopsy revealed collapsing focal segmental glomerulosclerosis (FSGS) in both th...
-
Article
Open AccessSynchronized turbo apoptosis induced by cold-shock
In our research on the role of apoptosis in the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE), we aim to evaluate the effects of early and late apoptotic cells and blebs on antigen ...
-
Article
Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+CD25+FoxP3+ T cells
Graft-versus-host-disease (GVHD) is the most common cause of poor outcome after allogeneic stem cell transplantation (SCT). Of late, exploitation of FOXP3+ regulatory T-cell (TREG) function is emerging as a promi...
-
Article
A randomised, prospective study on the conversion from cyclosporine–prednisone to cyclosporine–azathioprine at 6 months after renal transplantation
In a randomised prospective trial, we studied the effects of replacement of prednisone (Pred) by azathioprine (Aza), 6 months after transplantation, in stable renal allograft recipients on cyclosporine and pr...
-
Chapter and Conference Paper
Costs of drugs used after renal transplantation
There are no detailed data on the relative contributions to overall health care costs of the various drugs that are commonly used in renal transplant patients. We performed a cost analysis in 122 patients, usi...
-
Chapter and Conference Paper
Randomized trial of misoprostol in patients with chronic renal transplant rejection
Chronic vascular rejection is a major cause of long-term graft failure after renal transplantation. We investigated the effect of the addition of misoprostol (200 μg four times daily) to standard immunosuppres...
-
Chapter and Conference Paper
Post-transplant haemoglobin levels and host kidney status
Erythrocytosis after renal transplantation has been ascribed to inappropriate production of erythropoietin by the recipient’s native kidneys. In a retrospective analysis we examined the effect of pre-transplan...
-
Chapter and Conference Paper
Haemodynamic changes in human kidney allografts following administration of nifedipine: assessment with doppler spectrum analysis
Cyclosporin (CyA) has been demonstrated to increase the vascular resistance of renal allografts (RVR), whereas calcium channel blocking agents like nifedipine may counteract this effect. In this study RVR was ...
-
Article
Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters
Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules...
