18 Result(s)

Article

Persistence of expression of the TMPRSS2:ERG fusion gene after pre-surgery androgen ablation may be associated with early prostate specific antigen relapse of prostate cancer: Preliminary results

Background: The recently identified TM-PRSS2:ERG fusion gene is a candidate oncogene for prostate cancer (PCa). Subjects and methods: We have tested for the presence of this gene in tumor...

L. Bonaccorsi, G. Nesi, F. Nuti, M. Paglierani… in Journal of Endocrinological Investigation (2009)

Article

Prospective analysis of minimal bone marrow infiltration in pediatric Burkitt's lymphomas by long-distance polymerase chain reaction for t(8;14)(q24;q32)

The chromosomal translocation t(8;14)(q24;q32) represents a characteristic marker for Burkitt's lymphoma (BL). This translocation involves the MYC oncogene on chromosome 8 and the immunoglobulin heavy-chain (I...

L Mussolin, K Basso, M Pillon, E S d'Amore, A Lombardi, L Luzzatto, L Zanesco… in Leukemia (2003)

Article

Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (PNH): no evidence for intrinsic growth advantage of PNH clones

PNH is characterized by expansion of one or more stem cell clones with a PIG-A mutation, which causes a severe deficiency in the expression of glycosylphosphatidylinositol (GPI)-anchored proteins. There is eviden...

DJ Araten, M Bessler, S McKenzie, H Castro-Malaspina, BH Childs, F Boulad… in Leukemia (2002)

Chapter and Conference Paper

Genetic Factors in Malaria Resistance

A classical representation of the causation of human diseases is one in which every disease has both an inherited and an acquired component; it is only the relative weights of the two components that vary. Inf...

L. Luzzatto in Genes and Resistance to Disease (2000)

Article

About hemoglobins, G6PD and parasites in red cells

L. Luzzatto in Experientia (1995)

Article

Paroxysmal nocturnal hemoglobinuria: Correction of abnormal phenotype by somatic cell hybridization

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired blood disorder thought to result from a somatic mutation in a hemopoietic stem cell. PNH may evolve to aplastic anemia or to acute leukemia. PNH cells a...

P. Hillmen, M. Bessler, J. Bungey, L. Luzzatto in Somatic Cell and Molecular Genetics (1993)

Article

Molecular heterogeneity underlying the G6PD Mediterranean phenotype

As part of a study aiming to define the molecular basis of glucose-6-phosphate dehydrogenase (G6PD) deficiency, we analysed a sample from a Portugese boy with a family history of favism. Although the biochemic...

C. M. Corcoran, V. Calabrò, G. Tamagnini, M. Town, B. Haidar… in Human Genetics (1992)

Article

Intragenic interspecific complementation of glucose 6-phosphate dehydrogenase in human-hamster cell hybrids

A new variant of human glucose 6-phosphate dehydrogenase (G6PD), provisionally designated G6PD Harilaou, was observed in a Greek boy affected by severe hemolytic anemia. G6PD Harilaou was associated with very ...

M. Town, M. Athanasiou-Metaxa, L. Luzzatto in Somatic Cell and Molecular Genetics (1990)

Article

A simple disease with no cure

L. Luzzatto, P. Goodfellow in Nature (1989)

Article

Adaptation of Plasmodium falciparum to glucose 6-phosphate dehydrogenase-deficient host red cells by production of parasite-encoded enzyme

There is impressive evidence from geographical data^1,2, studies in the field³ and in vitro culture work^4–6 that genetically determined deficiency of glucose 6-phosphate dehydrogenase (G6PD) confers relative prote...

E. A. Usanga, L. Luzzatto in Nature (1985)

Chapter

Glucose-6-Phosphate Dehydrogenase

Genetic systems have been of interest to human genetics mainly because they exhibit polymorphism in various populations, and therefore seem to be relevant to human evolution, or because they are associated wit...

L. Luzzatto, G. Battistuzzi in Advances in Human Genetics 14 (1985)

Article

cDNA sequences of human glucose 6-phosphate dehydrogenase cloned in pBR322

Glucose 6-phosphate dehydrogenase (G6PD) catalyses the first reaction of the so-called oxidative pathway of glucose metabolism¹. In many cells, in addition to providing pentose sugars required for nucleic acid sy...

M. G. Persico, D. Toniolo, C. Nobile, M. D'Urso, L. Luzzatto in Nature (1981)

Article

Genetic heterogeneity of glucose 6-phosphate dehydrogenase deficiency in Sardinia

Glucose 6-phosphate dehydrogenase (G6PD) activity was assayed quantitatively in red cells from 100 consecutive G6PD-deficient newborn male babies born in a city hospital in Sassari, Sardinia. In four cases G6P...

U. Testa, T. Meloni, A. Lania, G. Battistuzzi, S. Cutillo, L. Luzzatto in Human Genetics (1980)

Article

Relationship between the Genes for Glucose-6-phosphate Dehydrogenase and for Haemoglobin in a Nigerian Population

VARIOUS contrasting data have been published concerning the incidence of glucose-6-phosphate dehydrogenase deficiency in subjects with normal and abnormal haemoglobins (reviewed in ref. 1). We have collected d...

L. LUZZATTO, N. C. ALLAN in Nature (1968)

Article

Nucleoside phosphorylase activity in guinea pig polymorphonuclear leukocytes

Gli autori dimostrano la presenza di nucleoside fosforilasi nei granulociti neutrofili di essudato peritoneale sterile di cavia. L'attività enzimatica è distribuita quasi totalmente nella frazione solubile, pr...

P. Calissano, G. Leoncini, L. Luzzatto in Experientia (1962)