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Persistent CD49d engagement in circulating CLL cells: a role for blood-borne ligands?
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Article
Application of molecular technologies for phosphoproteomic analysis of clinical samples
The integration of small kinase inhibitors and monoclonal antibodies into oncological practice has opened a new paradigm for treating cancer patients. As proteins are the direct targets of the new generations ...
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Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis
Acute myeloid leukemia (AML) primary cells express high levels of phosphorylated Akt, a master regulator of cellular functions regarded as a promising drug target. By means of reverse phase protein arrays, we ...
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Non-invasive monitoring and response prediction for rectal cancer undergoing neoadjuvant radiochemotherapy (RCT)