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  1. No Access

    Article

    The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

    Previously, it has been shown that pancreatic ductal adenocarcinoma (PDA) tumors exhibit high levels of hypoxia, characterized by low oxygen pressure (pO2) and decreased O2 intracellular perfusion. Chronic hypoxi...

    F F Blanco, M Jimbo, J Wulfkuhle, I Gallagher, J Deng, L Enyenihi… in Oncogene (2016)

  2. No Access

    Article

    Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation

    Resistance to therapies targeting the estrogen pathway remains a challenge in the treatment of estrogen receptor-positive breast cancer. To address this challenge, a systems biology approach was used. A librar...

    Y-W Zhang, R E Nasto, R Varghese, S A Jablonski, I G Serebriiskii, R Surana… in Oncogene (2016)

  3. No Access

    Article

    Application of molecular technologies for phosphoproteomic analysis of clinical samples

    The integration of small kinase inhibitors and monoclonal antibodies into oncological practice has opened a new paradigm for treating cancer patients. As proteins are the direct targets of the new generations ...

    M Pierobon, J Wulfkuhle, L Liotta, E Petricoin in Oncogene (2015)

  4. Article

    Open Access

    Chemoresistant colorectal cancer cells and cancer stem cells mediate growth and survival of bystander cells

    Recent studies suggest that cancer stem cells (CSCs) mediate chemoresistance, but interestingly, only a small percentage of cells in a resistant tumour are CSCs; this suggests that non-CSCs survive by other me...

    D Bose, L J Zimmerman, M Pierobon, E Petricoin, F Tozzi… in British Journal of Cancer (2011)

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