10 Result(s)
within
L. Landuzzi
Drug Resistance
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Article
Open AccessPreclinical validation of Aurora kinases-targeting drugs in osteosarcoma
Aurora kinases are key regulators of cell cycle and represent new promising therapeutic targets in several human tumours.
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Article
Open AccessHuman responses against HER-2-positive cancer cells in human immune system-engrafted mice
Human immune system (HIS)-engrafted mice are new tools to investigate human immune responses. Here, we used HIS mice to study human immune responses against human HER-2-positive cancer cells and their ability ...
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Article
Wild-type p53-mediated down-modulation of interleukin 15 and interleukin 15 receptors in human rhabdomyosarcoma cells
We recently reported that rhabdomyosarcoma cell lines express and secrete interleukin 15 (IL-15), a tightly regulated cytokine with IL-2-like activity. To test whether the p53-impaired function that is frequen...
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Article
Therapy of murine mammary carcinoma metastasis with interferon γ and MHC gene-transduced tumour cells
Gene-transfected tumour cells were used to cure mice bearing lung metastases by the parental, non-transduced mammary adenocarcinoma (TSA-pc). Repeated subcutaneous (s.c.) administrations of mitomycin C (MitC)-...
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Article
Redundancy of autocrine loops in human rhabdomyosarcoma cells: induction of differentiation by suramin
Three human rhabdomyosarcoma cell lines were used to investigate the presence of autocrine loops based on the production of insulin-like growth factor (IGF)-II, basic fibroblast growth factor (bFGF) and epider...
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Article
Decreased adhesion to endothelial cells and matrix proteins of H-2Kb gene transfected tumour cells
Transfection of murine metastatic B78H1 cells (derived from B16 melanoma) with a syngeneic H-2Kb gene was used to study the effect of Major Histocompatibility Complex (MHC) gene products on tumour cell adhesio...
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Article
Uncoupling of growth inhibition and differentiation in dexamethasone-treated human rhabdomyosarcoma cells
The effects of dexamethasone, a synthetic glucocorticoid, and of N,N-dimethylformamide on in vitro growth and differentiation and on proto-oncogene expression of human rhabdomyosarcoma cells were studied. RD/1...
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Article
Control of H-2 expression in transformed nonhaemopoietic cells by autocrine interferon
The relationship between autocrine interferon (IFN) production and the expression of class I Major Histocompatibility Complex (MHC) membrane glycoproteins in vitro was investigated in a panel of murine transfo...
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Article
Induction of myogenic differentiation in human rhabdomyosarcoma cells by ionising radiation, N,N-dimethylformamide and their combination
Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more...
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Article
In vitro differentiation of rhabdomyosarcomas induced by nickel or by Moloney murine sarcoma virus
In vitro cultures and clonal derivatives have been established from rat rhabdomyosarcomas induced by Moloney-Murine Sarcoma Virus (MSV) or by nickel sulfide; differentiation ability has been studied as express...
