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  1. Article

    Open Access

    Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins

    Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Gen...

    W D Hill, G Davies, L N van de Lagemaat, A Christoforou… in Translational Psychiatry (2014)

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    Article

    A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing

    Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality of life and loss of independence in old age. We investigated the genetic contribution to individual differences i...

    G Davies, S E Harris, C A Reynolds, A Payton, H M Knight… in Molecular Psychiatry (2014)

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    Article

    Genome-wide association studies establish that human intelligence is highly heritable and polygenic

    General intelligence is an important human quantitative trait that accounts for much of the variation in diverse cognitive abilities. Individual differences in intelligence are strongly associated with many im...

    G Davies, A Tenesa, A Payton, J Yang, S E Harris, D Liewald, X Ke… in Molecular Psychiatry (2011)

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    Article

    Antioxidant and B vitamin intake in relation to cognitive function in later life in the Lothian Birth Cohort 1936

    Cross-sectional and longitudinal studies provide some evidence for an association between intake of antioxidants and B vitamins, and cognitive function in later life, but intervention studies have not provided...

    G McNeill, X Jia, L J Whalley, H C Fox, J Corley… in European Journal of Clinical Nutrition (2011)

  5. No Access

    Article

    The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills

    A polymorphism (Val66Met) in the gene encoding brain-derived neurotrophic factor (BDNF) has previously been associated with impaired hippocampal function and scores on the Logical Memory subtest of the Wechsler M...

    S E Harris, H Fox, A F Wright, C Hayward, J M Starr, L J Whalley… in Molecular Psychiatry (2006)

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    Article

    In-patient major depression: is rolipram as effective as amitriptyline?

    The antidepressant efficacy and adverse-effects of rolipram (a dialkoxyphenyl-2-pyrrolidone) were compared to those of amitriptyline in the treatment of depressive illness requiring hospital admission in a dou...

    A. I. F. Scott, A. F. Perini, P. A. Shering… in European Journal of Clinical Pharmacology (1991)

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    Chapter

    Neuroendocrine Changes in Alzheimer’s Disease: Raised Plasma Concentrations of Growth Hormone and Thyroid Stimulating Hormone and Reduced Concentrations of Oestrogen-Stimulated Neurophysin

    The neuropathological (Ishii, 1965) and some of the neurochemical features of Alzheimer-type dementia (ATD) affect not only the cerebral cortex but also subcortical structures including the hypothalamus in whi...

    J. E. Christie, L. J. Whalley, J. Bennie, H. Dick… in Neuroendocrine Molecular Biology (1986)