121 Result(s)

Article

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere le...

Rebecca Keener, Surya B. Chhetri, Carla J. Connelly… in Nature Communications (2024)

Article

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni… in Nature (2023)

Article

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery of lipid-associated allel...

Margaret Sunitha Selvaraj, **hao Li, Zilin Li, Akhil Pampana… in Nature Communications (2022)

Article

A saturated map of common genetic variants associated with human height

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...

Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell… in Nature (2022)

Article

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a m...

Zhe Wang, Andrew Emmerich, Nicolas J. Pillon, Tim Moore, Daiane Hemerich… in Nature Genetics (2022)

Article

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program

The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage who...

Daniel DiCorpo, Sheila M. Gaynor, Emily M. Russell… in Communications Biology (2022)

Article

Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program

Deficiency of the immune checkpoint lymphocyte activation gene-3 (LAG3) protein is significantly associated with both elevated HDL-cholesterol (HDL-C) and myocardial infarction risk. We determined the associat...

Ani Manichaikul, Honghuang Lin, Chansuk Kang, Chaojie Yang… in Communications Biology (2022)

Article

Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels

Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of ...

Chloé Sarnowski, Mohsen Ghanbari, Joshua C. Bis, Mark Logue… in Communications Biology (2022)

Article

Rare coding variants in RCN3 are associated with blood pressure

While large genome-wide association studies have identified nearly one thousand loci associated with variation in blood pressure, rare variant identification is still a challenge. In family-based cohorts, geno...

Karen Y. He, Tanika N. Kelly, Heming Wang, **g**g Liang, Luke Zhu… in BMC Genomics (2022)

Article

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precis...

Brian E. Cade, Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen… in Genome Medicine (2021)

Article

Genome sequencing unveils a regulatory landscape of platelet reactivity

Platelet aggregation at the site of atherosclerotic vascular injury is the underlying pathophysiology of myocardial infarction and stroke. To build upon prior GWAS, here we report on 16 loci identified through...

Ali R. Keramati, Ming-Huei Chen, Benjamin A. T. Rodriguez… in Nature Communications (2021)

Article

Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

In modern Whole Genome Sequencing (WGS) epidemiological studies, participant-level data from multiple studies are often pooled and results are obtained from a single analysis. We consider the impact of differe...

Tamar Sofer, **uwen Zheng, Cecelia A. Laurie… in Nature Communications (2021)

Article

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now ana...

Pradeep Natarajan, Akhil Pampana, Sarah E. Graham… in Nature Communications (2021)

Article

Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes

A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03280-1.

Alexander G. Bick, Joshua S. Weinstock, Satish K. Nandakumar, Charles P. Fulco… in Nature (2021)