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  1. Article

    Open Access

    Inhibition of human positive cofactor 4 radiosensitizes human esophageal squmaous cell carcinoma cells by suppressing XLF-mediated nonhomologous end joining

    Radiotherapy has the widest application to esophageal squamous cell carcinoma (ESCC) patients. Factors associated with DNA damage repair have been shown to function in cell radiosensitivity. Human positive cof...

    D Qian, B Zhang, X-L Zeng, J M Le Blanc, Y-H Guo, C Xue, C Jiang… in Cell Death & Disease (2014)

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    Article

    Inhibition of transcriptional activation and cell proliferation activities of adenovirus E1A by the unique N-terminal domain of CtBP2

    The 243-residue E1A protein of adenovirus induces cellular proliferation, at least partly by regulating the transcription of cellular genes. This E1A function requires E1A N-terminal region and conserved regio...

    L-J Zhao, T Subramanian, G Chinnadurai in Oncogene (2008)

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    Article

    PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions

    C-terminal binding proteins (CtBPs) are cellular corepressors that are targeted by adenovirus E1A. A conserved motif of E1A (PLDLS) interacts with an N-terminal hydrophobic cleft of CtBPs. Many cellular cofact...

    L-J Zhao, T Subramanian, S Vijayalingam, G Chinnadurai in Oncogene (2007)

  4. No Access

    Article

    Genetic and Environmental Correlations of Bone Mineral Density at Different Skeletal Sites in Females and Males

    Bone mineral density (BMD) is a complex trait having genetic and environmental determination. There are gender-specific differences in BMD measurements, and the rate of BMD changes with age and lifestyle. Prev...

    T.-L. Yang, L.-J. Zhao, Y.-J. Liu, J.-F. Liu… in Calcified Tissue International (2006)

  5. No Access

    Article

    Genetic and Environmental Correlations between Age at Menarche and Bone Mineral Density at Different Skeletal Sites

    Low bone mineral density (BMD) is an important risk factor for osteoporotic fractures. Though previous studies have demonstrated that age at menarche (AAM) is phenotypically associated with BMD, the contributi...

    Y. Guo, L.-J. Zhao, H. Shen, Y. Guo, H.-W. Deng in Calcified Tissue International (2005)

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    Article

    A Second-Stage Genome Scan for QTLs Influencing BMD Variation

    Low bone mineral density (BMD) is a major risk factor for osteoporotic fracture. To identify genomic regions harboring quantitative trait loci (QTLs) contributing to BMD variation, we performed a two-stage gen...

    Q. -Y. Huang, F. -H. Xu, H. Shen, L. -J. Zhao… in Calcified Tissue International (2004)

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    Article

    Association of Estrogen Receptor α and Vitamin D Receptor Gene Polymorphisms with Bone Mineral Density in Chinese Males

    Osteoporosis is a common health problem not only in females but also in males, however, studies of osteoporosis in males are relatively rare compared to those in females. This is especially true in genetics st...

    J. R. Long, Y. Y. Zhang, P. Y. Liu, Y. J. Liu, H. Shen… in Calcified Tissue International (2004)

  8. No Access

    Article

    Demyelination but no cognitive, motor or behavioral deficits after adenovirus-mediated gene transfer into the brain

    Adenovirus-mediated gene transfer of interferon gamma (AdIFN) elicits rejection of intracerebral Lewis lung carcinoma. In this system, gene transfer into brain parenchymal cells is both necessary and sufficien...

    H M Fathallah-Shaykh, A I Kafrouni, L-J Zhao, R Diaz-Arrastia, J A Garcia… in Gene Therapy (2000)